Hsp90 inhibitor-loaded IR780 micelles for mitochondria-targeted mild-temperature photothermal therapy in xenograft models of human breast cancer
文献类型：期刊论文
| 作者 | Zhang, Tao; Wu, Bihan; Akakuru, Ozioma Udochukwu; Yao, Chenyang; Sun, Shan; Chen, Libin; Ren, Wenzhi; Wu, Aiguo; Huang, Pintong |
| 刊名 | CANCER LETTERS
 |
| 出版日期 | 2021 |
| 卷号 | 500 |
| 关键词 | IR-780 DYE BIIB021 NANOPARTICLES METABOLISM DELIVERY CELLS |
| 英文摘要 | Mitochondria-targeted mild-temperature photothermal therapy (MT-PTT) is a promising strategy that can maximize anticancer effects and reduce adverse reactions. Here, a novel photosensitizer with mitochondrial targeting based on IR780 iodide and heat shock protein 90 inhibitor (BIIB021), which can passively accumulate in MCF-7 cells and achieve effective MT-PTT effect is synthesized. The prepared PEG-IR780-BIIB021 nano-micelles possess considerable biocompatibility and biological stability, with an encapsulation efficiency of about 84% for BIIB021. They can selectively enrich in mitochondria, and release BIIB021 after NIR irradiation to reduce cell tolerance to heat, thereby reducing the mitochondrial membrane potential and rapidly affecting key intrinsic apoptotic factors (Cyt-C, Caspase-9, Bcl-2 and Bax) to achieve the effect of MT-PTT. It is believed that mitochondria-targeted MT-PTT generated by the PEG-IR780-BIIB021 nano-micelles is a promising therapeutic strategy in clinical practice. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/22155]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Wu, AG (corresponding author), Chinese Acad Sci, Zhejiang Engn Res Ctr Biomed Mat, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China. 2.Huang, PT (corresponding author), Zhejiang Univ, Dept Ultrasound Med, Affiliated Hosp 2, Sch Med, Hangzhou 310009, Peoples R China. 3.Ren, WZ 4.Wu, AG (corresponding author), Chinese Acad Sci, CAS Key Lab Magnet Mat & Devices, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Zhang, Tao,Wu, Bihan,Akakuru, Ozioma Udochukwu,et al. Hsp90 inhibitor-loaded IR780 micelles for mitochondria-targeted mild-temperature photothermal therapy in xenograft models of human breast cancer[J]. CANCER LETTERS,2021,500. |
| APA | Zhang, Tao.,Wu, Bihan.,Akakuru, Ozioma Udochukwu.,Yao, Chenyang.,Sun, Shan.,...&Huang, Pintong.(2021).Hsp90 inhibitor-loaded IR780 micelles for mitochondria-targeted mild-temperature photothermal therapy in xenograft models of human breast cancer.CANCER LETTERS,500. |
| MLA | Zhang, Tao,et al."Hsp90 inhibitor-loaded IR780 micelles for mitochondria-targeted mild-temperature photothermal therapy in xenograft models of human breast cancer".CANCER LETTERS 500(2021). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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