An intelligent T-1-T-2 switchable MRI contrast agent for the non-invasive identification of vulnerable atherosclerotic plaques dagger
文献类型：期刊论文
| 作者 | Pan, Chunshu; Lin, Junjie; Zheng, Jianjun; Liu, Chuang; Yuan, Bo; Akakuru, Ozioma Udochukwu; Zubair Iqbal, M.; Fang, Qianlan; Hu, Jiapeng; Chen, Jia |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2021 |
| 卷号 | 13期号:13页码:6461-6474 |
| 英文摘要 | Unlike stable atherosclerotic plaques, vulnerable plaques are very likely to cause serious cardio-cerebrovascular diseases. Meanwhile, how to non-invasively identify vulnerable plaques at early stages has been an urgent but challenging problem in clinical practices. Here, we propose a macrophage-targeted and in situ stimuli-triggered T-1-T-2 switchable magnetic resonance imaging (MRI) nanoprobe for the non-invasive diagnosis of vulnerable plaques. Precisely, single-dispersed iron oxide nanoparticles (IONPs) modified with hyaluronic acid (HA), denoted as IONP-HP, show macrophage targetability and T-1 MRI enhancement (r(2)/r(1) = 3.415). Triggered by the low pH environment of macrophage lysosomes, the single-dispersed IONP-HP transforms into a cluster analogue, which exhibits T-2 MRI enhancement (r(2)/r(1) = 13.326). Furthermore, an in vivo switch of T-1-T-2 enhancement modes shows that the vulnerable plaques exhibit strong T-1 enhancement after intravenous administration of the nanoprobe, followed by a switch to T-2 enhancement after 9 h. In contrast, stable plaques show only slight T-1 enhancement but without T-2 enhancement. It is therefore imperative that the intelligent and novel nanoplatform proposed in this study achieves a substantial non-invasive diagnosis of vulnerable plaques by means of a facile but effective T-1-T-2 switchable process, which will significantly contribute to the application of materials science in solving clinical problems. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/22164]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Jin, YH (corresponding author), Univ Chinese Acad Sci, Hwa Mei Hosp, Dept Radiol, Ningbo 315010, Peoples R China. 2.Wu, AG 3.Jin, YH (corresponding author), Univ Chinese Acad Sci, Ningbo Inst Life & Hlth Ind, Ningbo 315010, Peoples R China. 4.Chen, TX 5.Jin, YH (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Zhejiang Engn Res Ctr Biomed Mat, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China. 6.Jin, YH (corresponding author), Chinese Acad Sci, Key Lab Magnet Mat & Devices, Cixi Inst Biomed Engn, Int Cooperat Base Biomed Mat Technol & Applicat, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Pan, Chunshu,Lin, Junjie,Zheng, Jianjun,et al. An intelligent T-1-T-2 switchable MRI contrast agent for the non-invasive identification of vulnerable atherosclerotic plaques dagger[J]. NANOSCALE,2021,13(13):6461-6474. |
| APA | Pan, Chunshu.,Lin, Junjie.,Zheng, Jianjun.,Liu, Chuang.,Yuan, Bo.,...&Jin, Yinhua.(2021).An intelligent T-1-T-2 switchable MRI contrast agent for the non-invasive identification of vulnerable atherosclerotic plaques dagger.NANOSCALE,13(13),6461-6474. |
| MLA | Pan, Chunshu,et al."An intelligent T-1-T-2 switchable MRI contrast agent for the non-invasive identification of vulnerable atherosclerotic plaques dagger".NANOSCALE 13.13(2021):6461-6474. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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