Metal-Free Organo-Theranostic Nanosystem with High Nitroxide Stability and Loading for Image-Guided Targeted Tumor Therapy
文献类型：期刊论文
| 作者 | Akakuru, Ozioma U.; Xu, Chen; Liu, Chuang; Li, Zihou; Xing, Jie; Pan, Chunshu; Li, Yanying; Nosike, Elvis, I; Zhang, Zhoujing; Iqbal, Zubair M. |
| 刊名 | ACS NANO
 |
| 出版日期 | 2021 |
| 卷号 | 15期号:2页码:3079-3097 |
| 英文摘要 | The desire for all-organic-composed nanoparticles (NPs) of considerable biocompatibility to simultaneously diagnose and treat cancer is undeniably interminable. Heretofore, metal-based agents dominate the landscape of available magnetic resonance imaging (MRI) contrast agents and photothermal therapeutic agents, but with associated metal-specific downsides. Here, an all-organic metal-free nanoprobe, whose appreciable biocompatibility is synergistically contributed by its tetra-organo-components, is developed as a viable alternative to metal-based probes for MRI-guided tumor-targeted photothermal therapy (PTT). This rationally entails a glycol chitosan (GC)-linked polypyrrole (PP) nanoscaffold that provides abundant primary and secondary amino groups for amidation with the carboxyl groups in a nitroxide radical (TEMPO) and folic acid (FA), to obtain GC-PP@TEMPO-FA NPs. Advantageously, the appreciably benign GC-PP@TEMPO-FA features high nitroxide loading (r(1) = 1.58 mM(-1) s(-1)) and in vivo nitroxide-reduction resistance, prolonged nitroxide-systemic circulation times, appreciable water dispersibility, potential photodynamic therapeutic and electron paramagnetic resonance imaging capabilities, considerable biocompatibility, and ultimately achieves a 17 h commensurate MRI contrast enhancement. Moreover, its GC component conveys a plethora of PP to tumor sites, where FA-mediated tumor targeting enables substantial NP accumulation with consequential near-complete tumor regression within 16 days in an MRI-guided PTT. The present work therefore promotes the engineering of organic-based metal-free biocompatible NPs in synergism, in furtherance of tumor-targeted image-guided therapy. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/22168]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Wu, AG (corresponding author), Chinese Acad Sci, Key Lab Magnet Mat & Devices, Cixi Inst Biomed Engn Int Cooperat Base Biomed Ma, Ningbo 315201, Peoples R China. 2.Wu, AG (corresponding author), Chinese Acad Sci, Zhejiang Engn Res Ctr Biomed Mat, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Peoples R China. 3.Zheng, JJ (corresponding author), Univ Chinese Acad Sci, Hwa Mei Hosp, Ningbo 315010, Peoples R China. 4.Iqbal, ZM |
| 推荐引用方式 GB/T 7714 | Akakuru, Ozioma U.,Xu, Chen,Liu, Chuang,et al. Metal-Free Organo-Theranostic Nanosystem with High Nitroxide Stability and Loading for Image-Guided Targeted Tumor Therapy[J]. ACS NANO,2021,15(2):3079-3097. |
| APA | Akakuru, Ozioma U..,Xu, Chen.,Liu, Chuang.,Li, Zihou.,Xing, Jie.,...&Wu, Aiguo.(2021).Metal-Free Organo-Theranostic Nanosystem with High Nitroxide Stability and Loading for Image-Guided Targeted Tumor Therapy.ACS NANO,15(2),3079-3097. |
| MLA | Akakuru, Ozioma U.,et al."Metal-Free Organo-Theranostic Nanosystem with High Nitroxide Stability and Loading for Image-Guided Targeted Tumor Therapy".ACS NANO 15.2(2021):3079-3097. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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