Development of Novel Thermal Sprayed Hydroxyapatite-Rare Earth (HA-Re) Coatings for Potential Antimicrobial Applications in Orthopedics
文献类型：期刊论文
| 作者 | Yang, Chunling; Liu, Jin; Ren, Qianhong; Liu, Yi; Zhou, Ping; Li, Hua |
| 刊名 | JOURNAL OF THERMAL SPRAY TECHNOLOGY
 |
| 出版日期 | 2021 |
| 卷号 | 30期号:4页码:886-897 |
| 英文摘要 | Biofilm-associated infections and the lack of successful tissue integration of biomaterial surfaces are the two main barriers to the long-term service of implanted biomaterials. Development of novel biocompatible antimicrobial materials has provided insights into their potential biomedical applications. Many clinical studies have successfully proved that hydroxyapatite coating has excellent osteogenic activity but lacks antibacterial infection in the early stages after implantation. Rare earth (Re) elements have become promising antibacterial biocides and bone-forming effects. Antibacterial capacity of 14 rare earth elements (Eu, Gd, Ce, Nd, Y, La, Pr, Er, Sm, Ho, Tb, Yb, Lu, Dy) was assayed. The gadolinium (Gd) showed outstanding broad-spectrum antibacterial activity against both Gram-positive and Gram-positive bacteria. Here, we report Gd-HA coatings deposited on titanium (Ti) substrate by liquid thermal spraying. The grain size of Gd-HA decreased slightly after Gd3+ incorporation. The antibacterial properties of Gd-HA composite coatings were determined against Gram-negative pathogens Escherichia coli and Gram-positive pathogens Staphylococcus epidermidis. The anti-infection performances were assessed by examining bacteria adhesion and biofilm formation on the coatings. The in vitro cytotoxicity of the Gd-doped HA coatings was further measured on human osteoblast cell line by CCK-8 method. The thermal sprayed HA-Re composite coatings show improved antimicrobial and biocompatible properties and great applicable potential in orthopedics. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/22273]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Liu, Y (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Marine Mat & Related Technol, Zhejiang Key Lab Marine Mat & Protect Technol, Ningbo 315201, Peoples R China. 2.Liu, Y (corresponding author), Chinese Acad Sci, Zhejiang Engn Res Ctr Biomed Mat, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Peoples R China. 3.Liu, Y (corresponding author), Jiangxi Acad Sci, Inst Appl Phys, Nanchang 330029, Jiangxi, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Yang, Chunling,Liu, Jin,Ren, Qianhong,et al. Development of Novel Thermal Sprayed Hydroxyapatite-Rare Earth (HA-Re) Coatings for Potential Antimicrobial Applications in Orthopedics[J]. JOURNAL OF THERMAL SPRAY TECHNOLOGY,2021,30(4):886-897. |
| APA | Yang, Chunling,Liu, Jin,Ren, Qianhong,Liu, Yi,Zhou, Ping,&Li, Hua.(2021).Development of Novel Thermal Sprayed Hydroxyapatite-Rare Earth (HA-Re) Coatings for Potential Antimicrobial Applications in Orthopedics.JOURNAL OF THERMAL SPRAY TECHNOLOGY,30(4),886-897. |
| MLA | Yang, Chunling,et al."Development of Novel Thermal Sprayed Hydroxyapatite-Rare Earth (HA-Re) Coatings for Potential Antimicrobial Applications in Orthopedics".JOURNAL OF THERMAL SPRAY TECHNOLOGY 30.4(2021):886-897. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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