Black titanium dioxide@manganese dioxide for glutathione-responsive MR imaging and enhanced photothermal therapy
文献类型：期刊论文
| 作者 | Gao, Yang; Yin, Zhibin; Ji, Qian; Jiang, Jiabing; Tao, Zhengzheng; Zhao, Xiaolong; Sun, Sijia; Wu, Aiguo; Zeng, Leyong |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2021 |
| 卷号 | 9期号:2页码:314-321 |
| 关键词 | TUMOR-MICROENVIRONMENT TIO2 NANOCOMPOSITES |
| 英文摘要 | Multifunctional nanoprobes with tumor microenvironment response are playing important roles in highly efficient theranostics of cancers. Herein, a kind of theranostic nanoprobe was synthesized by coating manganese dioxide (MnO2) on the surface of black commercial P25 titanium dioxide (b-P25). The resultant nanoprobe (b-P25@MnO2) possessed glutathione (GSH)-responsive magnetic resonance (MR) imaging and enhanced photothermal therapy (PTT). In tumor microenvironments, the excessive GSH was consumed by reacting with MnO2 to generate Mn2+ for GSH-responsive MR imaging, in which the longitudinal relaxation rate of b-P25@MnO2 was up to 30.44 mM(-1) s(-1), showing excellent cellular and intratumoraI MR imaging. Moreover, the prepared b-P25@MnO2 exhibited stable and strong photothermal conversion capability with a high photothermal conversion efficiency of 30.67%, by which the 4T1 tumors disappeared completely, indicating safe and highly efficient PTT performance. The current work developed GSH-responsive b-P25@MnO2 nanoprobes, demonstrated for MR imaging and enhanced PTT in cancers. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/22290]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2021专题_期刊论文 |
| 作者单位 | 1.Ji, Q (corresponding author), Tianjin Med Univ, Dept Radiol, Tianjin Cent Hosp 1, Cent Clin Coll 1, Tianjin 300192, Peoples R China. 2.Zeng, LY (corresponding author), Hebei Univ, Coll Chem & Environm Sci, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag,Minist Educ,Inst Life, Baoding 071002, Peoples R China. 3.Wu, AG (corresponding author), Chinese Acad Sci, Cixi Inst Biomed Engn, CAS Key Lab Magnet Mat & Devices, Ningbo Inst Mat Technol & Engn, Ningbo 3152D1, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Gao, Yang,Yin, Zhibin,Ji, Qian,et al. Black titanium dioxide@manganese dioxide for glutathione-responsive MR imaging and enhanced photothermal therapy[J]. JOURNAL OF MATERIALS CHEMISTRY B,2021,9(2):314-321. |
| APA | Gao, Yang.,Yin, Zhibin.,Ji, Qian.,Jiang, Jiabing.,Tao, Zhengzheng.,...&Zeng, Leyong.(2021).Black titanium dioxide@manganese dioxide for glutathione-responsive MR imaging and enhanced photothermal therapy.JOURNAL OF MATERIALS CHEMISTRY B,9(2),314-321. |
| MLA | Gao, Yang,et al."Black titanium dioxide@manganese dioxide for glutathione-responsive MR imaging and enhanced photothermal therapy".JOURNAL OF MATERIALS CHEMISTRY B 9.2(2021):314-321. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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