Magnetically switchable mechano-chemotherapy for enhancing the death of tumour cells by overcoming drug-resistance
文献类型：期刊论文
| 作者 | Yao, Chenyang; Yang, Fang; Sun, Li; Ma, Yuanyuan; Stanciu, Stefan G.; Li, Zihou; Liu, Chuang; Akakuru, Ozioma Udochukwu; Xu, Lipeng; Hampp, Norbert |
| 刊名 | NANO TODAY
 |
| 出版日期 | 2020 |
| 卷号 | 35 |
| 关键词 | IRON-OXIDE NANOPARTICLES MULTIDRUG-RESISTANCE BREAST-CANCER DELIVERY APOPTOSIS THERAPY RELEASE SIZE |
| 英文摘要 | The emergence of drug-resistant tumour cells significantly interferes with the effectiveness of chemotherapeutic treatment plans and represents a major obstacle in the ongoing quest to overcome cancers. Therefore, exploring in detail new therapeutic strategies that can obviate this important challenge is regarded as a very important topic at the time being. Herein, we propose a non-invasive and remotely controllable mechano-chemotherapeutic approach that relies on the use of a rotating magnetic field (RMF) of low intensity (45 m T) in combination with a therapeutic agent consisting of a composite nanomaterial comprised of a poly(lactic-co-glycolic acid) (PLGA) shell co-loaded with Zn0.2Fe2.8O4 magnetic nanoparticles (mNPs) and Doxorubicin (DOX). We show that RMF exposure induces a mechanical movement to this nanomaterial, which can be exploited for (i) controllably releasing the anti-cancer drug for chemotherapy, and (ii) promoting the death of tumour cells by means of mechanical forces exerted onto their membranes. Such dual behavior leads to combating cancer cells via different and complementary routes enabling a controllable and efficient therapy. The proposed model enables controllable tumor therapy by precisely operating the magnetic nanomaterials at the nanometer scale, and its applicability is neither restricted to the nanomaterial here demonstrated nor to solely addressing cancer. Modified variants of the proposed model, together with the corresponding therapeutic agents, can be developed to address other pathologies, enabling novel therapeutic approaches that exceed the precision and efficiency of current ones. (C) 2020 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/22396]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2020专题_期刊论文 2021专题_期刊论文 |
| 作者单位 | 1.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Zhejiang Engn Res Ctr Biomed Mat, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China. 2.Wu, AG (corresponding author), Chinese Acad Sci, CAS Key Lab Magnet Mat & Devices, Cixi Inst Biomed Engn, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China. 3.Yang, F |
| 推荐引用方式 GB/T 7714 | Yao, Chenyang,Yang, Fang,Sun, Li,et al. Magnetically switchable mechano-chemotherapy for enhancing the death of tumour cells by overcoming drug-resistance[J]. NANO TODAY,2020,35. |
| APA | Yao, Chenyang.,Yang, Fang.,Sun, Li.,Ma, Yuanyuan.,Stanciu, Stefan G..,...&Wu, Aiguo.(2020).Magnetically switchable mechano-chemotherapy for enhancing the death of tumour cells by overcoming drug-resistance.NANO TODAY,35. |
| MLA | Yao, Chenyang,et al."Magnetically switchable mechano-chemotherapy for enhancing the death of tumour cells by overcoming drug-resistance".NANO TODAY 35(2020). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。