Automatic Segmentation and Visualization of Choroid in OCT with Knowledge Infused Deep Learning
文献类型：期刊论文
| 作者 | Zhang, Huihong; Yang, Jianlong; Zhou, Kang; Li, Fei; Hu, Yan; Zhao, Yitian; Zheng, Ce; Zhang, Xiulan; Liu, Jiang |
| 刊名 | IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
 |
| 出版日期 | 2020 |
| 卷号 | 24期号:12页码:3408-3420 |
| 关键词 | OPTICAL COHERENCE TOMOGRAPHY DIABETIC-RETINOPATHY LAYER SEGMENTATION LAMINA-CRIBROSA THICKNESS IMAGES VOLUME ENHANCEMENT VASCULARITY REMOVAL |
| 英文摘要 | The choroid provides oxygen and nourishment to the outer retina thus is related to the pathology of various ocular diseases. Optical coherence tomography (OCT) is advantageous in visualizing and quantifying the choroid in vivo. However, its application in the study of the choroid is still limited for two reasons. (1) The lower boundary of the choroid (choroid-sclera interface) in OCT is fuzzy, which makes the automatic segmentation difficult and inaccurate. (2) The visualization of the choroid is hindered by the vessel shadows from the superficial layers of the inner retina. In this paper, we propose to incorporate medical and imaging prior knowledge with deep learning to address these two problems. We propose a biomarker-infused global-to-local network (Bio-Net) for the choroid segmentation, which not only regularizes the segmentation via predicted choroid thickness, but also leverages a global-to-local segmentation strategy to provide global structure information and suppress overfitting. For eliminating the retinal vessel shadows, we propose a deep-learning pipeline, which firstly locate the shadows using their projection on the retinal pigment epithelium layer, then the contents of the choroidal vasculature at the shadow locations are predicted with an edge-to-texture generative adversarial inpainting network. The results show our method outperforms the existing methods on both tasks. We further apply the proposed method in a clinical prospective study for understanding the pathology of glaucoma, which demonstrates its capacity in detecting the structure and vascular changes of the choroid related to the elevation of intra-ocular pressure. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/22415]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2020专题_期刊论文 2021专题_期刊论文 |
| 作者单位 | Yang, JL (corresponding author), Chinese Acad Sci, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Zhang, Huihong,Yang, Jianlong,Zhou, Kang,et al. Automatic Segmentation and Visualization of Choroid in OCT with Knowledge Infused Deep Learning[J]. IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS,2020,24(12):3408-3420. |
| APA | Zhang, Huihong.,Yang, Jianlong.,Zhou, Kang.,Li, Fei.,Hu, Yan.,...&Liu, Jiang.(2020).Automatic Segmentation and Visualization of Choroid in OCT with Knowledge Infused Deep Learning.IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS,24(12),3408-3420. |
| MLA | Zhang, Huihong,et al."Automatic Segmentation and Visualization of Choroid in OCT with Knowledge Infused Deep Learning".IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS 24.12(2020):3408-3420. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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