Navigating nMOF-mediated enzymatic reactions for catalytic tumor-specific therapy
文献类型：期刊论文
| 作者 | Liu, Chuang; Yao, Junlie; Hu, Jiapeng; Akakuru, Ozioma Udochukwu; Sun, Shan; Chen, Tianxiang; Wu, Aiguo |
| 刊名 | MATERIALS HORIZONS
 |
| 出版日期 | 2020 |
| 卷号 | 7期号:12页码:3176-3186 |
| 关键词 | METAL-ORGANIC FRAMEWORKS CANCER GOLD STARVATION NANOZYMES |
| 英文摘要 | Nanoscale metal-organic frameworks (nMOFs), exhibiting highly designable structures, multiple surface functionalities, and well-defined porous apertures, have spurred intensive research as superior antitumor candidates with great promise. Tailored to the specific tumor microenvironment (TME), emerging nMOF-based enzymatic nanocatalysts, (i) nMOFs with intrinsic enzyme-mimicking performance, and (ii) enzyme- and (iii) nanozyme-engineered nMOFs, have secured their place as magic bullets, producing dramatic and tumor-specific therapeutic outcomes. Here, this review concentrates on the advances and recent developments in various nMOF-mediated enzymatic reactions toward the internal stimuli of the TME (acidosis, high-glucose conditions, and the overproduction of glutathione, hydrogen peroxide, and lactate). We also set forth challenges and offer insights relating to accelerating the exploration of nMOFs as catalytic tumor-specific therapeutic agents. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/22417]  |
| 专题 | 中国科学院宁波材料技术与工程研究所 2020专题_期刊论文 2021专题_期刊论文 |
| 作者单位 | 1.Chen, TX 2.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Zhejiang Engn Res Ctr Biomed Mat, Cixi Inst Biomed Engn,CAS Key Lab Magnet Mat & De, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Liu, Chuang,Yao, Junlie,Hu, Jiapeng,et al. Navigating nMOF-mediated enzymatic reactions for catalytic tumor-specific therapy[J]. MATERIALS HORIZONS,2020,7(12):3176-3186. |
| APA | Liu, Chuang.,Yao, Junlie.,Hu, Jiapeng.,Akakuru, Ozioma Udochukwu.,Sun, Shan.,...&Wu, Aiguo.(2020).Navigating nMOF-mediated enzymatic reactions for catalytic tumor-specific therapy.MATERIALS HORIZONS,7(12),3176-3186. |
| MLA | Liu, Chuang,et al."Navigating nMOF-mediated enzymatic reactions for catalytic tumor-specific therapy".MATERIALS HORIZONS 7.12(2020):3176-3186. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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