Cationic peptide-based salt-responsive antibacterial hydrogel dressings for wound healing
文献类型：期刊论文
| 作者 | Yuan, Jingfeng; Zhang, Dong; He, Xiaomin; Ni, Yifeng; Che, Lingbin; Wu, Jiang; Wu, Baoyi; Wang, Yang; Wang, Shuguang; Sha, Dongyong |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2021 |
| 卷号 | 190页码:754-762 |
| 关键词 | FABRICATION MEMBRANES CELLULOSE |
| 英文摘要 | Development of biological dressings has received widespread attentions due to their good breathability, biocompatibility, wettability, and the ability to absorb wound exudate without sticking to the wound. However, current proposed antibacterial hydrogels are limited antibacterial ability, short service life and insufficient biocompatibility, which are still challenging to address intricate practical applications. Here we develop a cationic peptide-based, salt-responsive hydrogel dressing with triple functions of antifouling, bactericidal, and bacterial release by combining epsilon-poly-L-lysine, poly(ethylene glycol) diglycidyl ether, and poly(DVBAPS-co-GMA) via a one-pot method. These designed hydrogels enabled to further quaternize to enhance antibacterial property due to the presence of amine residues. The resultant hydrogels present good antibacterial activity (>90%), biocompatibility, cell proliferation efficacy (-400%) and adhesiveness. Through in vivo and in vitro antibacterial capability tests, it is also found that hydrogels have good antifouling and sterilization capabilities, and the sterilization rate could reach up to -96%. In addition, -94% of the attached bacterial can be released after saline/water switching for several cycles. Taken together, the designed multiple antibacterial dressing prolongs the lifespan relying on reversible salt-responsive release and meet special requirements for wound healing. This work not only provides a platform to highlight its promising potentials in wound management but also gives a custom strategy to biomedical applications. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/21332]  |
| 专题 | 2021专题_期刊论文 |
| 作者单位 | 1.Yang, JT (corresponding author), Zhejiang Univ Technol, Coll Mat Sci & Engn, Hangzhou 310014, Peoples R China. 2.Zhang, D (corresponding author), Univ Akron, Coll Engn & Polymer Sci, Dept Chem Bimol & Corros Engn, Akron, OH 44325 USA. 3.Wu, J (corresponding author), Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China. 4.Zheng, SY |
| 推荐引用方式 GB/T 7714 | Yuan, Jingfeng,Zhang, Dong,He, Xiaomin,et al. Cationic peptide-based salt-responsive antibacterial hydrogel dressings for wound healing[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,190:754-762. |
| APA | Yuan, Jingfeng.,Zhang, Dong.,He, Xiaomin.,Ni, Yifeng.,Che, Lingbin.,...&Yang, Jintao.(2021).Cationic peptide-based salt-responsive antibacterial hydrogel dressings for wound healing.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,190,754-762. |
| MLA | Yuan, Jingfeng,et al."Cationic peptide-based salt-responsive antibacterial hydrogel dressings for wound healing".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 190(2021):754-762. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。