Polypyrrole-based nanotheranostic agent for MRI guided photothermal-chemodynamic synergistic cancer therapy
文献类型：期刊论文
| 作者 | Zhou, Bangyi; Yin, Chenhui; Feng, Qiang; Wu, Yiting; Pan, Xiaoyu; Liu, Chuang; Tian, Jinjin; Geng, Siqi; Wang, Kexin; Xing, Jie |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2021 |
| 卷号 | 13期号:45页码:19085-19097 |
| 关键词 | GLUTATHIONE-DEPLETION CARBON NANOTUBES NANOPARTICLES PLATFORM CELLS CO |
| 英文摘要 | Polypyrrole (PPy) nanoparticles have been widely studied in tumor photothermal therapy (PTT) for their significant photostability, good biocompatibility, and excellent photothermal performance. Herein, we report bovine serum albumin (BSA) stabilized PPy that were mineralized by MnO2 nanozyme on the surface (PPy@BSA-MnO2) to achieve synergistic photothermal and chemodynamic therapy (CDT) for breast cancer. In this multifunctional nanoplatform, the surface-loaded MnO2 undergoes a redox reaction with glutathione (GSH) to generate glutathione disulfide (GSSG) and Mn2+. Then, Mn2+ can convert H2O2 into a highly cytotoxic OH to achieve chemodynamic therapy (CDT) and possess good magnetic resonance (MR) T-1-weighted imaging capabilities to realize contrast imaging of the 4T1 tumor-bearing mouse models. In addition, PPy nanoparticles can efficiently convert near-infrared light energy into heat and achieve PTT. Most importantly, PPy@BSA-MnO2 nanoprobes have excellent in vitro 4T1 cell-killing effect and in vivo tumor-suppressive properties. The acute toxicity assessment results indicate that PPy@BSA-MnO2 nanoprobes have good biological safety. Therefore, the as-prepared multifunctional PPy@BSA-MnO2 nanoprobes possess excellent performance to promote MRI-guided PTT/CDT synergistic therapy for breast cancer treatment and have extensive clinical transformation and application prospects. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/21361]  |
| 专题 | 2021专题_期刊论文 |
| 作者单位 | 1.Yu, ZS (corresponding author), Shaoxing Univ, Med Sci Res Ctr, Sch Med, Lab Nanomed, Shaoxing City 312000, Zhejiang, Peoples R China. 2.Wu, AG (corresponding author), Chinese Acad Sci, Zhejiang Engn Res Ctr Biomed Mat, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn,CAS Key Lab Magnet, Ningbo 315201, Zhejiang, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Zhou, Bangyi,Yin, Chenhui,Feng, Qiang,et al. Polypyrrole-based nanotheranostic agent for MRI guided photothermal-chemodynamic synergistic cancer therapy[J]. NANOSCALE,2021,13(45):19085-19097. |
| APA | Zhou, Bangyi.,Yin, Chenhui.,Feng, Qiang.,Wu, Yiting.,Pan, Xiaoyu.,...&Wu, Aiguo.(2021).Polypyrrole-based nanotheranostic agent for MRI guided photothermal-chemodynamic synergistic cancer therapy.NANOSCALE,13(45),19085-19097. |
| MLA | Zhou, Bangyi,et al."Polypyrrole-based nanotheranostic agent for MRI guided photothermal-chemodynamic synergistic cancer therapy".NANOSCALE 13.45(2021):19085-19097. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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