Circulating neutrophil gelatinase-associated lipocalin and gestational diabetes mellitus: a meta-analysis
文献类型：期刊论文
| 作者 | Chen, Zhu; Huang, Hui; Hu, Jingcen; Wane, Shuyu; Xia, Liang |
| 刊名 | CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
 |
| 出版日期 | 2021 |
| 卷号 | 48期号:5页码:1206-1214 |
| 关键词 | CLASSIFICATION HYPERGLYCEMIA PREGNANCY OBESITY DIET |
| 英文摘要 | Background: Many studies have assessed the role of circulating neutrophil gelatinase-associated lipocalin (NGAL) on the risk of gestational diabetes mellitus (GDM), but the results remain uncertain. Thus, this study aimed to assess the association between NGAL and GDM risk by performing a meta-analysis. Methods: We carried out a systematic search of electronic databases (PubMed, Embase, Wanfang and Chinese National Knowledge Infrastructure databases) to retrieve all related studies. The estimates of standardized mean difference (SMD) and its 95% confidence interval (CI) were calculated in a random-effects model. Between-study heterogeneity was assessed using I-2. Results: Of all included 17 studies, 1080 pregnant women with GDM and 1736 controls were finally included in our analysis. The overall estimate indicated that circulating NGAL levels were higher in the GDM cases comparing to normal pregnant women (SMD: 3.16; 95% CI: 2.28, 4.04; p < 0.001). In stratified analyses, larger differences were observed in women with maternal age <30 years compared to those with maternal age >= 30 years (SMD 4.23 vs. 1.30), and among studies with BMI not matched compared to BMI matched studies (SMD: 4.29 vs. 2.63), but no difference was observed in Caucasian population (SMD: 1.68; 95% CI: -0.68, 3.99; p = 0.157). Conclusion: Our findings show that elevated levels of circulating NGAL might be more likely to be found among GDM women. Circulating NGAL might be a helpful detecting marker for the judgment of the occurrence of GDM. Nevertheless, further prospective studies are needed to assess this potential role. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/21382]  |
| 专题 | 2021专题_期刊论文 |
| 作者单位 | 1.Xia, L (corresponding author), Univ Chinese Acad Sci, Ningbo Inst Life & Hlth Ind, Ningbo 31501, Zhejiang, Peoples R China. 2.Xia, L (corresponding author), Univ Chinese Acad Sci, Hwa Mei Hosp, Key Lab Diag & Treatment Digest Syst Tumors Zheji, Ningbo 315201, Zhejiang, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Chen, Zhu,Huang, Hui,Hu, Jingcen,et al. Circulating neutrophil gelatinase-associated lipocalin and gestational diabetes mellitus: a meta-analysis[J]. CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY,2021,48(5):1206-1214. |
| APA | Chen, Zhu,Huang, Hui,Hu, Jingcen,Wane, Shuyu,&Xia, Liang.(2021).Circulating neutrophil gelatinase-associated lipocalin and gestational diabetes mellitus: a meta-analysis.CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY,48(5),1206-1214. |
| MLA | Chen, Zhu,et al."Circulating neutrophil gelatinase-associated lipocalin and gestational diabetes mellitus: a meta-analysis".CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY 48.5(2021):1206-1214. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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