An intelligent tumor microenvironment responsive nanotheranostic agent for T1/T2 dual-modal magnetic resonance imaging-guided and self-augmented photothermal therapy
文献类型：期刊论文
| 作者 | Yao, Junlie; Zheng, Fang; Yang, Fang; Yao, Chenyang; Xing, Jie; Li, Zihou; Sun, Sijia; Chen, Jia; Xu, Xiawei; Cao, Yi |
| 刊名 | BIOMATERIALS SCIENCE
 |
| 出版日期 | 2021 |
| 卷号 | 9期号:22页码:7591-7602 |
| 关键词 | NANOPARTICLES CHEMOTHERAPY |
| 英文摘要 | Photothermal therapy (PTT), as a promising antineoplastic therapeutic strategy, has been harnessed to restrain tumor growth through near-infrared (NIR) irradiation mediated thermal ablation. Nevertheless, its biological applications are hampered by thermal diffusion and up-regulated heat shock proteins (HSPs). Herein, a versatile nanotheranostic agent is developed via integrating Zn0.2Fe2.8O4 nanoparticles (NPs), polydopamine (PDA), and MnO2 NPs for T1/T2 dual-modal magnetic resonance (MR) imaging-guided and self-augmented PTT. The as-designed Zn0.2Fe2.8O4@PDA@MnO2 NPs adequately serve as a PTT agent to realize effective photothermal conversion and obtain local hyperthermia. Additionally, the Zn0.2Fe2.8O4@PDA@MnO2 NPs can significantly consume overexpressed glutathione (GSH) and generate Mn2+ in the tumor microenvironment (TME), thus destroying redox homeostasis and catalytically generating hydroxyl radicals (OH) for HSP suppression and PTT enhancement. Meanwhile, Mn2+ and Zn0.2Fe2.8O4 NPs significantly strengthen T1- and T2-weighted MR contrast for tumor imaging and PTT guidance. Hence, this study offers proof of concept for self-augmented PTT and T1/T2 dual-modal MR imaging for tumor elimination. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/21410]  |
| 专题 | 2021专题_期刊论文 |
| 作者单位 | 1.Yang, F 2.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Magnet Mat & Devices, Cixi Inst Biomed Engn, Ningbo 315201, Peoples R China. 3.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Zhejiang Engn Res Ctr Biomed Mat, Ningbo 315201, Peoples R China. 4.Wu, AG (corresponding author), Adv Energy Sci & Technol Guangdong Lab, Huizhou 516000, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Yao, Junlie,Zheng, Fang,Yang, Fang,et al. An intelligent tumor microenvironment responsive nanotheranostic agent for T1/T2 dual-modal magnetic resonance imaging-guided and self-augmented photothermal therapy[J]. BIOMATERIALS SCIENCE,2021,9(22):7591-7602. |
| APA | Yao, Junlie.,Zheng, Fang.,Yang, Fang.,Yao, Chenyang.,Xing, Jie.,...&Wu, Aiguo.(2021).An intelligent tumor microenvironment responsive nanotheranostic agent for T1/T2 dual-modal magnetic resonance imaging-guided and self-augmented photothermal therapy.BIOMATERIALS SCIENCE,9(22),7591-7602. |
| MLA | Yao, Junlie,et al."An intelligent tumor microenvironment responsive nanotheranostic agent for T1/T2 dual-modal magnetic resonance imaging-guided and self-augmented photothermal therapy".BIOMATERIALS SCIENCE 9.22(2021):7591-7602. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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