Retinoic Acid-Loaded Dendritic Polyglycerol-Conjugated Gold Nanostars for Targeted Photothermal Therapy in Breast Cancer Stem Cells
文献类型：期刊论文
| 作者 | Pan, Yuanwei; Ma, Xuehua; Liu, Chuang; Xing, Jie; Zhou, Suqiong; Parshad, Badri; Schwerdtle, Tanja; Li, Wenzhong; Wu, Aiguo; Haag, Rainer |
| 刊名 | ACS NANO
 |
| 出版日期 | 2021 |
| 卷号 | 15期号:9页码:15069-15084 |
| 关键词 | CO-DELIVERY NANOPARTICLES DOXORUBICIN NANOPLATFORM INHIBITION NANORODS TUMORS |
| 英文摘要 | The existence of cancer stem cells (CSCs) poses a major obstacle for the success of current cancer therapies, especially the fact that non-CSCs can spontaneously turn into CSCs, which lead to the failure of the treatment and tumor relapse. Therefore, it is very important to develop effective strategies for the eradication of the CSCs. In this work, we have developed a CSCs-specific targeted, retinoic acid (RA)-loaded gold nanostars-dendritic polyglycerol (GNSs-dPG) nanoplatform for the efficient eradication of CSCs. The nanocomposites possess good biocompatibility and exhibit effective CSCs-specific multivalent targeted capability due to hyaluronic acid (HA) decorated on the multiple attachment sites of the bioinert dendritic polyglycerol (dPG). With the help of CSCs differentiation induced by RA, the self-renewal of breast CSCs and tumor growth were suppressed by the high therapeutic efficacy of photothermal therapy (PTT) in a synergistic inhibitory manner. Moreover, the stemness gene expression and CSC-driven tumorsphere formation were significantly diminished. In addition, the in vivo tumor growth and CSCs were also effectively eliminated, which indicated superior anticancer activity, effective CSCs suppression, and prevention of relapse. Taken together, we developed a CSCs-specific targeted, RA-loaded GNSs-dPG nanoplatform for the targeted eradication of CSCs and for preventing the relapse. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/21464]  |
| 专题 | 2021专题_期刊论文 |
| 作者单位 | 1.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices, Cixi Inst Biomed Engn, Ningbo 315201, Peoples R China. 2.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo 315201, Peoples R China. 3.Li, WZ 4.Haag, R (corresponding author), Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany. |
| 推荐引用方式 GB/T 7714 | Pan, Yuanwei,Ma, Xuehua,Liu, Chuang,et al. Retinoic Acid-Loaded Dendritic Polyglycerol-Conjugated Gold Nanostars for Targeted Photothermal Therapy in Breast Cancer Stem Cells[J]. ACS NANO,2021,15(9):15069-15084. |
| APA | Pan, Yuanwei.,Ma, Xuehua.,Liu, Chuang.,Xing, Jie.,Zhou, Suqiong.,...&Haag, Rainer.(2021).Retinoic Acid-Loaded Dendritic Polyglycerol-Conjugated Gold Nanostars for Targeted Photothermal Therapy in Breast Cancer Stem Cells.ACS NANO,15(9),15069-15084. |
| MLA | Pan, Yuanwei,et al."Retinoic Acid-Loaded Dendritic Polyglycerol-Conjugated Gold Nanostars for Targeted Photothermal Therapy in Breast Cancer Stem Cells".ACS NANO 15.9(2021):15069-15084. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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