The role of BDNF exon I region methylation in the treatment of depression with sertraline and its clinical diagnostic value
文献类型：期刊论文
| 作者 | Xing, Yuhua; Sun, Ting; Li, Guangxue; Xu, Guoan; Cheng, Jia; Gao, Shugui |
| 刊名 | JOURNAL OF CLINICAL LABORATORY ANALYSIS
 |
| 出版日期 | 2021 |
| 卷号 | 35期号:11 |
| 关键词 | NEUROTROPHIC-FACTOR BDNF PROMOTER METHYLATION DNA-METHYLATION SERUM ASSOCIATION RISK |
| 英文摘要 | Background Brain-derived neurotrophic factor (BDNF) is considered to be one of the best candidate genes for depression. However, whether sertraline treatment affects the methylation level of this gene remains unknown. Methods Fifty-three patients with depression and 51 healthy controls were included in the study. The methylation level of BDNF exon I was determined in blood samples from these subjects. The Hamilton Depression Scale was used to evaluate the depression status of patients. Single nucleotide polymorphism detection was used for genotyping, and a receiver operating characteristic (ROC) curve was used to evaluate the predictive value of the methylation level of this locus in patients with depression. Results There was a significant difference in the methylation level of BDNF exon I between the control and depression groups. No effect of sertraline monotherapy on BDNF methylation was found in subjects with depression. Moreover, no interaction was found between BDNF genotype and the per cent methylation of BDNF exon I. However, methylation at this site was positively correlated with diurnal variation and retardation scores. Blood homocysteine concentrations were significantly reduced by sertraline treatment. No influence of genotype on serum BDNF concentration was found in subjects with depression. The ROC curve showed that methylation of BDNF exon I may be used to distinguish patients from healthy people, to a certain extent. Conclusion Methylation of BDNF exon I may be used as a biomarker of depression and may be a therapeutic target for previously untreated depression. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/21493]  |
| 专题 | 2021专题_期刊论文 |
| 作者单位 | 1.Gao, SG (corresponding author), Ningbo Kangning Hosp, Dept Affect Disorder, Ningbo 315201, Zhejiang, Peoples R China. 2.Cheng, J |
| 推荐引用方式 GB/T 7714 | Xing, Yuhua,Sun, Ting,Li, Guangxue,et al. The role of BDNF exon I region methylation in the treatment of depression with sertraline and its clinical diagnostic value[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2021,35(11). |
| APA | Xing, Yuhua,Sun, Ting,Li, Guangxue,Xu, Guoan,Cheng, Jia,&Gao, Shugui.(2021).The role of BDNF exon I region methylation in the treatment of depression with sertraline and its clinical diagnostic value.JOURNAL OF CLINICAL LABORATORY ANALYSIS,35(11). |
| MLA | Xing, Yuhua,et al."The role of BDNF exon I region methylation in the treatment of depression with sertraline and its clinical diagnostic value".JOURNAL OF CLINICAL LABORATORY ANALYSIS 35.11(2021). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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