A Smart Glutathione and H2O2 Dual-Responsive Signal Inversion Magnetic Resonance Imaging Contrast Agent for Tumor Diagnosis
文献类型：期刊论文
| 作者 | Li Zi-Hou; Qian Kun; Ozioma-Udochukwu, Akakuru; Pan Chun-Shu; Ma Xue-Hua; Han Ying-Ying; Zheng Jian-Jun; Cui Ping; Wei Gang; Shen Zhe-Yu |
| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2021 |
| 卷号 | 49期号:8页码:E21141-E21150 |
| 关键词 | MRI NANOPARTICLES |
| 英文摘要 | Accurate bioimaging of internal body tissues plays a key role in achieving precise medical diagnosis. Magnetic resonance imaging (MRI) as one of the clinically used bioimaging modalities is largely hampered by the occurrence of false-positive imaging (artifacts). The use of contrast agents has tremendously contributed to the improvement of the accuracy of MRI, however, developing a dual-responsive contrast agent that capable of effectively switching from T-2 to T-1 contrast enhancement in vivo still remains a challenge. Here, we demonstrated the synthesis of a glutathione (GSH) and H2O2 dual-responsive signal inversion contrast agent, which mainly comprised of superparamagnetic iron oxide nanoparticles (SPION) and degradable mesoporous silica nanoparticles (DMSN). The contrast agent achieved T-2-weighted imaging in tumor site, and enabled an efficacious switch to T-1-weighted imaging upon the GSH- and H2O2-mediated degradation of DMSN. The characteristics of the signal transformation largely reduced the artifacts to enhance the accuracy of MRI. Interestingly, the in vivo evaluations revealed prominence of the T-2-weighted imaging up to 2 h post-intravenous injection, which was succeeded by T1-weighted imaging that gradually increased with time and became dominant after 24 h. It was therefore expected that the findings shown in this work would guide the development of other contrast agents alike for more robust and accurate bioimaging by using MRI. |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/21592]  |
| 专题 | 2021专题_期刊论文 |
| 作者单位 | 1.Wu, AG (corresponding author), Chinese Acad Sci, Cixi Inst Biomed Engn, Int Cooperat Base Biomed Mat Technol & Applicat, Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China. 2.Shen, ZY 3.Wu, AG (corresponding author), Chinese Acad Sci, Zhejiang Engn Res Ctr Biomed Mat, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Li Zi-Hou,Qian Kun,Ozioma-Udochukwu, Akakuru,et al. A Smart Glutathione and H2O2 Dual-Responsive Signal Inversion Magnetic Resonance Imaging Contrast Agent for Tumor Diagnosis[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2021,49(8):E21141-E21150. |
| APA | Li Zi-Hou.,Qian Kun.,Ozioma-Udochukwu, Akakuru.,Pan Chun-Shu.,Ma Xue-Hua.,...&Wu Ai-Guo.(2021).A Smart Glutathione and H2O2 Dual-Responsive Signal Inversion Magnetic Resonance Imaging Contrast Agent for Tumor Diagnosis.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,49(8),E21141-E21150. |
| MLA | Li Zi-Hou,et al."A Smart Glutathione and H2O2 Dual-Responsive Signal Inversion Magnetic Resonance Imaging Contrast Agent for Tumor Diagnosis".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 49.8(2021):E21141-E21150. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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