中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Nanosized drug delivery systems modulate the immunosuppressive microenvironment to improve cancer immunotherapy

文献类型：期刊论文

作者Yan, Wen-lu4,5,6; Lang, Tian-qun3,5,6; Yuan, Wen-hui4,5,6; Yin, Qi3,4,5,6; Li, Ya-ping1,2,4,5,6
刊名ACTA PHARMACOLOGICA SINICA
出版日期2022-09-01
页码10
关键词immunotherapy nanosized drug delivery systems (NDDSs) immunosuppressive tumor microenvironment (ITME) immunogenetic cell death (ICD) tumor vaccine
ISSN号1671-4083
DOI10.1038/s41401-022-00976-6
通讯作者Yin, Qi(qyin@simm.ac.cn) ; Li, Ya-ping(ypli@simm.ac.cn)
英文摘要Immunotherapy that activates immune systems for combating cancer has yielded considerable clinical benefits recently. However, the immunosuppressive tumor microenvironment (ITME) is a major hurdle to immunotherapy as it supports tumor to evade immune surveillance. Reversing ITME facilitates the recruitment and activation of antitumor immune cells, thereby promoting immunotherapy. Our group has developed various nanosized drug delivery systems (NDDSs) to modulate ITME with enhanced efficacy and safety. In the review we introduce the ITME-remodeling strategies for improving immunotherapy based on NDDSs including triggering tumor cells to undergo immunogenetic cell death (ICD), applying tumor vaccine, and directly regulating intratumoral immune components (immune cells or cytokines). In order to guide the design of NDDSs for amplified effects of antitumor immunotherapy, the contributions and future directions of this field are also discussed.
WOS关键词IMMUNOGENIC CELL-DEATH ; ANTIGEN-PRESENTING CELLS ; COMBINATION ; RESISTANCE ; BLOCKADE ; ACID
资助项目National Natural Science Foundation of China[81871471] ; National Natural Science Foundation of China[31930066] ; National Natural Science Foundation of China[32130058] ; National Natural Science Foundation of China[32171315] ; Natural Science Foundation of Shanghai[19ZR1479900] ; Science and Technology Commission of Shanghai Municipality[19431900800] ; International Partnership Program of CAS[153631KYSB20190013] ; Natural Science Foundation of Shandong[ZR2019ZD25] ; Special Research Assistant Project of CAS ; China Postdoctoral Science Foundation[2020M681428] ; Shanghai Postdoctoral Excellence Program[2020495]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000848701400001
出版者NATURE PUBL GROUP
源URL[http://119.78.100.183/handle/2S10ELR8/302096]  
专题新药研究国家重点实验室
通讯作者Yin, Qi; Li, Ya-ping
作者单位1.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
3.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China
4.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Yan, Wen-lu,Lang, Tian-qun,Yuan, Wen-hui,et al. Nanosized drug delivery systems modulate the immunosuppressive microenvironment to improve cancer immunotherapy[J]. ACTA PHARMACOLOGICA SINICA,2022:10.
APA Yan, Wen-lu,Lang, Tian-qun,Yuan, Wen-hui,Yin, Qi,&Li, Ya-ping.(2022).Nanosized drug delivery systems modulate the immunosuppressive microenvironment to improve cancer immunotherapy.ACTA PHARMACOLOGICA SINICA,10.
MLA Yan, Wen-lu,et al."Nanosized drug delivery systems modulate the immunosuppressive microenvironment to improve cancer immunotherapy".ACTA PHARMACOLOGICA SINICA (2022):10.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。