Artemisinin derivative SM934 in the treatment of autoimmune and inflammatory diseases: therapeutic effects and molecular mechanisms
文献类型：期刊论文
| 作者 | Tong, Xiao1,2; Chen, Li1,2; He, Shi-jun1,2 ; Zuo, Jian-ping1,2
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2022-09-01 |
| 页码 | 7 |
| 关键词 | artemisinin derivative beta-aminoarteether maleate (SM934) autoimmune and inflammatory diseases T helper cells macrophages inflammatory cytokines |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-022-00978-4 |
| 通讯作者 | He, Shi-jun(heshijun@simm.ac.cn) ; Zuo, Jian-ping(jpzuo@simm.ac.cn) |
| 英文摘要 | Artemisinin and its derivatives are the well-known anti-malarial drugs derived from a traditional Chinese medicine. In addition to antimalarial, artemisinin and its derivatives possess distinguished anti-cancer, anti-oxidant, anti-inflammatory and anti-viral activities, but the poor solubility and low bioavailability hinder their clinical application. In the last decades a series of new watersoluble and oil-soluble derivatives were synthesized. Among them, we have found a water-soluble derivative beta-aminoarteether maleate (SM934) that exhibits outstanding suppression on lymphocytes proliferation in immunosuppressive capacity and cytotoxicity screening assays with 35-fold higher potency than dihydroartemisinin. SM934 displays significant therapeutic effects on various autoimmune and inflammatory diseases, including systemic lupus erythematosus, antiphospholipid syndrome nephropathy, membranous nephropathy, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, and dry eye disease. Here, we summarize the immunomodulatory effects, anti-inflammatory, anti-oxidative and anti-fibrosis activities of SM934 in disease-relevant animal models and present the probable pharmacological mechanisms involved in its therapeutic efficacy. This review also delineates a typical example of natural product-based drug discovery, which might further vitalize natural product exploration and development in pharmacotherapy. |
| WOS关键词 | NF-KAPPA-B ; SIGNALING PATHWAY ; IMMUNOSUPPRESSIVE ACTIVITY ; ARTESUNATE ; MICE ; EXPRESSION ; MALARIA ; ACIDS |
| 资助项目 | National Natural Science Foundation of China[81871240] ; Science and Technology Commission of Shanghai Municipality Natural Science Foundation of Shanghai[22ZR1473700] ; Science and Technology Commission of Shanghai Municipality[21S11911000] ; Science and Technology Commission of Shanghai Municipality[21S11907700] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000848701400002 |
| 出版者 | NATURE PUBL GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302099]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | He, Shi-jun; Zuo, Jian-ping |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tong, Xiao,Chen, Li,He, Shi-jun,et al. Artemisinin derivative SM934 in the treatment of autoimmune and inflammatory diseases: therapeutic effects and molecular mechanisms[J]. ACTA PHARMACOLOGICA SINICA,2022:7. |
| APA | Tong, Xiao,Chen, Li,He, Shi-jun,&Zuo, Jian-ping.(2022).Artemisinin derivative SM934 in the treatment of autoimmune and inflammatory diseases: therapeutic effects and molecular mechanisms.ACTA PHARMACOLOGICA SINICA,7. |
| MLA | Tong, Xiao,et al."Artemisinin derivative SM934 in the treatment of autoimmune and inflammatory diseases: therapeutic effects and molecular mechanisms".ACTA PHARMACOLOGICA SINICA (2022):7. |
入库方式： OAI收割
来源：上海药物研究所
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