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The Obesity Amelioration Effect in High-Fat-Diet Fed Mice of a Homogeneous Polysaccharide from Codonopsis pilosula

文献类型：期刊论文

作者Su, Qi1,2,3; Huo, Jiangyan1,2; Wang, Yibin1,2; Zhou, Yang1,2; Luo, Dan1,2; Hou, Jinjun1,2; Zhang, Zijia1,2; Long, Huali1,2; Zhong, Xianchun1,2; Xie, Cen1,2
刊名MOLECULES
出版日期2022-08-01
卷号27期号:16页码:13
关键词Codonopsis pilosula polysaccharide structural characterization obesity
DOI10.3390/molecules27165348
通讯作者Lei, Min(mlei@simm.ac.cn) ; Liu, Yameng(yameng_liu@simm.ac.cn) ; Wu, Wanying(wanyingwu@simm.ac.cn)
英文摘要A homogeneous polysaccharide coded as CPP-1 was extracted and purified from the root of Codonopsis pilosula (Franch.) Nannf. by water extraction, ethanol precipitation, and column chromatography. Its structure was analyzed by HPGPC-ELSD, HPLC, GC-MS, FT-IR, and NMR techniques. The results indicated that CPP-1 was composed of mannose (Man), glucose (Glc), galactose (Gal), and arabinose (Ara) at a molar ratio of 5.86 : 51.69 : 34.34 : 8.08. The methylation analysis revealed that the main glycosidic linkage types of CPP-1 were (1 ->)-linked-Glc residue, (1 -> 3)-linked-Glc residues, (1 -> 4)-linked-Gal residue, (1 -> 2,3,4)-linked-Glc residue, (1 ->)-linked-Man residue, (1 -> 3,4)-linked-Glc residue, and (1 ->)-linked-Ara residue. In vivo efficacy trial illustrated that CPP-1 supplements could alleviate HFD-induced mice obesity significantly, as well as improve obesity-induced disorders of glucose metabolism, alleviate insulin resistance, and improve the effects of lipid metabolism. The findings indicate that this polysaccharide has the potential for the treatment of obesity.
WOS关键词STRUCTURAL-CHARACTERIZATION ; IN-VITRO
资助项目Key Research and Development Projects in Guangdong Province of China[2020B1111110001] ; Shanghai Municipal Science and Technology Major Project
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000845427200001
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/302108]  
专题中国科学院上海药物研究所
通讯作者Lei, Min; Liu, Yameng; Wu, Wanying
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Su, Qi,Huo, Jiangyan,Wang, Yibin,et al. The Obesity Amelioration Effect in High-Fat-Diet Fed Mice of a Homogeneous Polysaccharide from Codonopsis pilosula[J]. MOLECULES,2022,27(16):13.
APA Su, Qi.,Huo, Jiangyan.,Wang, Yibin.,Zhou, Yang.,Luo, Dan.,...&Wu, Wanying.(2022).The Obesity Amelioration Effect in High-Fat-Diet Fed Mice of a Homogeneous Polysaccharide from Codonopsis pilosula.MOLECULES,27(16),13.
MLA Su, Qi,et al."The Obesity Amelioration Effect in High-Fat-Diet Fed Mice of a Homogeneous Polysaccharide from Codonopsis pilosula".MOLECULES 27.16(2022):13.

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来源：上海药物研究所

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