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Boron-Assisted Selective Citrulline Modification under Mild Conditions

文献类型：期刊论文

作者Zhao, Hailong3,5; Shan, Aidong4; Liang, Yunshi3,5; Wu, Haiting3,5; He, Yiting3,5; Chen, Huihong3,5; Zeng, Jiaxin1,3; Gu, Jiangyong2; Song, Jian-Ping3,5; Qiu, Hong4
刊名ORGANIC LETTERS
出版日期2022-08-23
页码5
ISSN号1523-7060
DOI10.1021/acs.orglett.2c02722
通讯作者Gu, Jiangyong(gujy@gzucm.edu.cn) ; Song, Jian-Ping(songjp@gzucm.edu.cn) ; Qiu, Hong(hongqiu@simm.ac.cn) ; Zhang, Jing(jingzhang@gzucm.edu.cn)
英文摘要Protein citrullination is one type of protein post-translational modification. Previous methods entail the use of a strongly acidic condition (pH <1), which impedes its exploration under physiological and pathological conditions. Here, we developed a biocompatible method based on o-boron-assisted citrulline modification. We demonstrated that this method enables selective and mainly irreversible modification of citrulline residues under neutral conditions. We expect that it will provide a valuable tool for the study of protein citrullination.
WOS关键词CHEMICAL BIOLOGY ; PROTEIN ; PHENYLGLYOXAL ; INHIBITION ; PROBE ; ACIDS
资助项目Guangzhou University of Chinese Medicine ; Shanghai Institute of Materia Medica ; Chinese Academy of Sciences
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000848112000001
源URL[http://119.78.100.183/handle/2S10ELR8/302120]  
专题中国科学院上海药物研究所
通讯作者Gu, Jiangyong; Song, Jian-Ping; Qiu, Hong; Zhang, Jing
作者单位1.Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 510405, Guangdong, Peoples R China
2.Guangzhou Univ Chinese Med, Res Ctr Integrat Med, Sch Basic Med Sci, Guangzhou 510006, Peoples R China
3.Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 510405, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
5.Guangzhou Univ Chinese Med, Artemisinin Res Ctr, Guangzhou 510405, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Hailong,Shan, Aidong,Liang, Yunshi,et al. Boron-Assisted Selective Citrulline Modification under Mild Conditions[J]. ORGANIC LETTERS,2022:5.
APA Zhao, Hailong.,Shan, Aidong.,Liang, Yunshi.,Wu, Haiting.,He, Yiting.,...&Zhang, Jing.(2022).Boron-Assisted Selective Citrulline Modification under Mild Conditions.ORGANIC LETTERS,5.
MLA Zhao, Hailong,et al."Boron-Assisted Selective Citrulline Modification under Mild Conditions".ORGANIC LETTERS (2022):5.

入库方式： OAI收割

来源：上海药物研究所

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