ICAM1 promotes bone metastasis via integrin-mediated TGF-beta/EMT signaling in triple-negative breast cancer
文献类型：期刊论文
| 作者 | Chen, Mingcang3,4; Wu, Chunyu2; Fu, Zhengwei4; Liu, Sheng1 |
| 刊名 | CANCER SCIENCE
 |
| 出版日期 | 2022-08-26 |
| 页码 | 15 |
| ISSN号 | 1347-9032 |
| 关键词 | bone metastasis epithelial-to-mesenchymal transition intercellular adhesion molecule 1 TGF-beta/SMAD signaling triple-negative breast cancer |
| DOI | 10.1111/cas.15532 |
| 通讯作者 | Fu, Zhengwei(azwfu@zjut.edu.cn) ; Liu, Sheng(sliu_tcm@163.com) |
| 英文摘要 | Bone-related events caused by breast cancer bone metastasis substantially compromise the survival and quality of life of patients. Because triple-negative breast cancer (TNBC) lacks hormone receptors and Her2-targeted therapeutic options, progress in the treatment of TNBC bone metastasis has been very slow. Intercellular adhesion molecule 1 (ICAM1) is highly expressed in various cancers and plays an important role in tumorigenesis and metastasis. However, the effect and mechanism of ICAM1 in TNBC bone metastasis are still unknown. We found that ICAM1 was highly expressed in TNBC and correlated with prognosis in TNBC patients. Cell lines with high expression of ICAM1 exhibited enhanced bone metastasis in tumor-bearing mice, and silencing ICAM1 expression significantly inhibited bone metastasis in mice. ICAM1 interacted with integrins to activate the epithelial-to-mesenchymal transition program through TGF-beta/SMAD signaling, ultimately enhancing cell invasiveness. Therefore, the findings of the present study provide a strong rationale for the application of ICAM1-targeted therapy in TNBC patients with bone metastasis. |
| WOS关键词 | ADHESION ; EMT ; LFA-1 ; NEUTROPHILS ; INHIBITION ; ACTIVATION ; MAC-1 ; CELLS |
| 资助项目 | Shanghai Hospital Development Center[SHDC2020CR1050B] ; Science and Technology Commission of Shanghai Municipality[20Z21900300] ; Shanghai Municipal Health Commission[ZY3-LCPT--2--1002] ; National Natural Science Foundation of China[81704075] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000844572700001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302132]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Fu, Zhengwei; Liu, Sheng |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Longhua Hosp, 725 South Wanping Rd, Shanghai 200032, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Breast Surg Integrated Tradit & Western Med, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 4.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, 18 Chaowang Rd, Hangzhou 311112, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Mingcang,Wu, Chunyu,Fu, Zhengwei,et al. ICAM1 promotes bone metastasis via integrin-mediated TGF-beta/EMT signaling in triple-negative breast cancer[J]. CANCER SCIENCE,2022:15. |
| APA | Chen, Mingcang,Wu, Chunyu,Fu, Zhengwei,&Liu, Sheng.(2022).ICAM1 promotes bone metastasis via integrin-mediated TGF-beta/EMT signaling in triple-negative breast cancer.CANCER SCIENCE,15. |
| MLA | Chen, Mingcang,et al."ICAM1 promotes bone metastasis via integrin-mediated TGF-beta/EMT signaling in triple-negative breast cancer".CANCER SCIENCE (2022):15. |
入库方式： OAI收割
来源：上海药物研究所
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