Sequentially Activatable Polypeptide Nanoparticles for Combinatory Photodynamic Chemotherapy of Breast Cancer
文献类型：期刊论文
| 作者 | Zhang, Huijuan3,4; Pan, Jiaxing2,3; Wang, Tingting1; Lai, Yi3; Liu, Xiaoying3; Chen, Fangmin3; Xu, Leiming2; Qu, Xiongwei4; Hu, Xiuli4; Yu, Haijun3
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| 刊名 | ACS APPLIED MATERIALS & INTERFACES
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| 出版日期 | 2022-08-24 |
| 页码 | 12 |
| 关键词 | stimulus responsive polypeptide nanoparticles photodynamic therapy breast cancer precise tumor therapy |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.2c09064 |
| 通讯作者 | Lai, Yi(laiyi@simm.ac.cn) ; Qu, Xiongwei(xwqu@hebut.edu.cn) ; Hu, Xiuli(huxiuli@hebut.edu.cn) ; Yu, Haijun(hjyu@simm.ac.cn) |
| 英文摘要 | Stimuli-activatable nanomaterials hold significant promise for tumor-specific drug delivery by recognizing the internal or external stimulus. Herein, we reported a dual-responsive and biodegradable polypeptide nanoparticle (PPTP@PTX2 NP) for combinatory chemotherapy and photodynamic therapy (PDT) of breast cancer. The NPs were engineered by encapsulating diselenide bond linked dimeric prodrug of paclitaxel (PTX2) in an intracellular acidity-activatable polypeptide micelle. Specifically, the acid-responsive polypeptide was synthesized by grafting a tetraphenyl porphyrin (TPP) photosensitizer and N,N-diisopropy-lethylenediamine (DPA) onto the poly(ethylene glycol)-block- poly(glutamic acid) diblock copolymer by the amidation reaction, which self-assembled into micellar NPs and was activated inside the acidic endocytic vesicles to perform PDT. The paclitaxel dimer can be stably loaded into the polypeptide NPs and be restored by PDT inside the tumor cells. The formed PPTP@PTX2 NPs remained inert during blood circulation and passively accumulated in the tumor foci, which could be activated within the endocytic vesicles via acid-triggered protonation of DPA groups to generate fluorescence signal and release PTX(2 )in 4T1 murine breast tumor cells. Upon 660 nm laser irradiation, the activated NPs carried out PDT via TPP and chemotherapy via PTX to induce apoptosis of 4T1 cells and thereby efficiently inhibited 4T1 tumor growth and prevented metastasis of tumor cells. |
| WOS关键词 | PRODRUG NANOPARTICLES ; DRUG-RESISTANCE ; ACID ; MECHANISMS ; MICELLES |
| 资助项目 | National Natural Science Foundation of China[51973213] ; Lingang Laboratory[LG-QS-202206-04] ; China Postdoctoral Science Foundation[2021M700157] ; Shanghai Post-Doctoral Excellence Program[2021424] ; e National Facility for Protein Science in Shanghai (NFPS) |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000848603200001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302147]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lai, Yi; Qu, Xiongwei; Hu, Xiuli; Yu, Haijun |
| 作者单位 | 1.Tongji Univ, Shanghai Peoples Hosp 10, Ultrasound Res & Educ Inst, Sch Med,Dept Med Ultrasound, Shanghai 200072, Peoples R China 2.Shanghai Jiaotong Univ Sch Med, Xinhua Hosp, Dept Gastroenterol, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Ctr Pharmaceut, Shanghai 201203, Peoples R China 4.Hebei Univ Technol, Inst Polymer Sci & Engn, Sch Chem Engn, Tianjin 300130, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Huijuan,Pan, Jiaxing,Wang, Tingting,et al. Sequentially Activatable Polypeptide Nanoparticles for Combinatory Photodynamic Chemotherapy of Breast Cancer[J]. ACS APPLIED MATERIALS & INTERFACES,2022:12. |
| APA | Zhang, Huijuan.,Pan, Jiaxing.,Wang, Tingting.,Lai, Yi.,Liu, Xiaoying.,...&Yu, Haijun.(2022).Sequentially Activatable Polypeptide Nanoparticles for Combinatory Photodynamic Chemotherapy of Breast Cancer.ACS APPLIED MATERIALS & INTERFACES,12. |
| MLA | Zhang, Huijuan,et al."Sequentially Activatable Polypeptide Nanoparticles for Combinatory Photodynamic Chemotherapy of Breast Cancer".ACS APPLIED MATERIALS & INTERFACES (2022):12. |
入库方式： OAI收割
来源：上海药物研究所
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