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Deep chemical identification of phytoecdysteroids in Achyranthes bidentata Blume by UHPLC coupled with linear ion trap-Orbitrap mass spectrometry and targeted isolation

文献类型：期刊论文

作者Wang Ying-Ying2,3; Li Jia-Yuan2; Yao Chang-Liang2; Zhang Jian-Qing2; Yu Yang1,2; Yao Shuai2; Gao Min1,2; Wu Shi-Fei2; Wei Wen-Long2; Bi Qi-Rui2
刊名CHINESE JOURNAL OF NATURAL MEDICINES
出版日期2022-07-01
卷号20期号:7页码:551-560
ISSN号2095-6975
关键词Achyranthes bidentata Blume Chemical identification Fragmentation behaviors Phytoecdysteroids Targeted isolation
DOI10.1016/S1875-5364(22)60185-7
通讯作者Guo De-An(daguo@simm.ac.cn)
英文摘要Achyranthes bidentata Blume is widely used as a traditional Chinese medicine with the effects of nourishing the liver and kidneys and strengthening muscles and bones. In this work, a rapid and simple strategy was developed for characterizing phytoecdysteroids by ultra-high-performance liquid chromatography coupled with liner ion trap-Orbitrap mass spectrometry using electrospray ionization in the negative mode. As a result, 47 phytoecdysteroids were unambiguously or tentatively characterized. Among them, seven known compounds were identified according to the reference standards along with molecular formula, retention time and fragmentation patterns, while others were mostly potential new compounds. Through targeted isolation, the structures of three new compounds were determined by NMR spectra, which were consistent with LC-MS characterization. The present study provides an efficient method to deeply characterize phytoecdysteroids.
WOS关键词ROOTS ; EXTRACT
WOS研究方向Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种英语
出版者CHINESE JOURNAL NATURAL MEDICINES
WOS记录号WOS:000841687300008
源URL[http://119.78.100.183/handle/2S10ELR8/302284]  
专题中国科学院上海药物研究所
通讯作者Guo De-An
作者单位1.Univ Chinese Acad Sci, Sch Pharmaceut Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Wang Ying-Ying,Li Jia-Yuan,Yao Chang-Liang,et al. Deep chemical identification of phytoecdysteroids in Achyranthes bidentata Blume by UHPLC coupled with linear ion trap-Orbitrap mass spectrometry and targeted isolation[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2022,20(7):551-560.
APA Wang Ying-Ying.,Li Jia-Yuan.,Yao Chang-Liang.,Zhang Jian-Qing.,Yu Yang.,...&Guo De-An.(2022).Deep chemical identification of phytoecdysteroids in Achyranthes bidentata Blume by UHPLC coupled with linear ion trap-Orbitrap mass spectrometry and targeted isolation.CHINESE JOURNAL OF NATURAL MEDICINES,20(7),551-560.
MLA Wang Ying-Ying,et al."Deep chemical identification of phytoecdysteroids in Achyranthes bidentata Blume by UHPLC coupled with linear ion trap-Orbitrap mass spectrometry and targeted isolation".CHINESE JOURNAL OF NATURAL MEDICINES 20.7(2022):551-560.

入库方式： OAI收割

来源：上海药物研究所

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