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Gold Nanocage-Based Photothermal Ablation Facilitates In Situ Vaccination for Melanoma Therapy

文献类型：期刊论文

作者Zhang, Meng3,4,5,6; Chen, Yingzhi4,5; Li, Dongdong5; He, Zhidi5; Wang, Hairui5; Wu, Aihua5; Fei, Weidong6; Zheng, Caihong6; Liu, Ergang3; Huang, Yongzhuo1,2,3,4,5
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2022-08-18
页码12
ISSN号1944-8244
关键词gold nanocages photothermal therapy in situ vaccination JQ1 tumor microenvironment
DOI10.1021/acsami.2c10842
通讯作者Liu, Ergang(liuergang@zidd.ac.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要Cancer immunotherapy represents a medical break-through, but there are still many patients unable to benefit from it because of the low response rate. The immunosuppressive tumor microenvironment (TME) is the main barrier to immunotherapy. Alleviating intratumoral immunosuppression is critical for improv-ing the immune therapeutic efficacy. This work developed an in situ vaccination strategy by using gold nanocage (AuNC)-based photothermal effect in combination with an adjuvant and PD-L1 suppressor. In specific, this therapeutic strategy included three components: AuNCs as an inducer for tumor antigen production via photothermal ablation, CpG oligodeoxynucleotides as an adjuvant to amplify immune responses, and JQ1 as a PD-L1 suppressor to inhibit an immune checkpoint. The results showed that the in situ vaccination efficiently activated dendritic cells and primed T cells and exhibited a high therapeutic efficacy in the melanoma-bearing mice. This therapeutic strategy can increase the infiltration of cytotoxic T lymphocytes, suppress the PD-L1 expression in the tumor, and repolarize tumor-associated macrophages from pro-tumor M2 to the anti-tumor M1 phenotype, thereby remodeling the TME via regulating the innate immune and adaptive immune responses.
资助项目National Key Research and Development Program of China[2021TYFC00600] ; National Key Research and Development Program of China[2021YFE0103100] ; National Natural Science Foundation of China[81925035] ; Shanghai SciTech Innovation Initiative[19431903100] ; Shanghai SciTech Innovation Initiative[18430740800] ; Department of Science and Technology of Guangdong Province[2019B090904008] ; Department of Science and Technology of Guangdong Province[2021B0909050003]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000844309400001
源URL[http://119.78.100.183/handle/2S10ELR8/302302]  
专题新药研究国家重点实验室
通讯作者Liu, Ergang; Huang, Yongzhuo
作者单位1.Taizhou Univ, Inst Nat Med & Hlth Prod, Sch Adv Study, Taizhou 318000, Peoples R China
2.Natl Med Prod Adm, Key Lab Qual Res & Evaluat Pharmaceut Excipients, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
6.Zhejiang Univ, Womens Hosp, Sch Med, Dept Pharm, Hangzhou 310006, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Meng,Chen, Yingzhi,Li, Dongdong,et al. Gold Nanocage-Based Photothermal Ablation Facilitates In Situ Vaccination for Melanoma Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2022:12.
APA Zhang, Meng.,Chen, Yingzhi.,Li, Dongdong.,He, Zhidi.,Wang, Hairui.,...&Huang, Yongzhuo.(2022).Gold Nanocage-Based Photothermal Ablation Facilitates In Situ Vaccination for Melanoma Therapy.ACS APPLIED MATERIALS & INTERFACES,12.
MLA Zhang, Meng,et al."Gold Nanocage-Based Photothermal Ablation Facilitates In Situ Vaccination for Melanoma Therapy".ACS APPLIED MATERIALS & INTERFACES (2022):12.

入库方式： OAI收割

来源：上海药物研究所

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