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Atractylone Alleviates Ethanol-Induced Gastric Ulcer in Rat with Altered Gut Microbiota and Metabolites

文献类型：期刊论文

作者Li, Ling3,4; Du, Yaoyao4; Wang, Yang2; He, Ning3; Wang, Bing1,4; Zhang, Tong4
刊名JOURNAL OF INFLAMMATION RESEARCH
出版日期2022
卷号15页码:4709-4723
关键词atractylone gastric ulcer inflammation oxidative stress gut microbiota metabolomics
DOI10.2147/JIR.S372389
通讯作者Wang, Bing(bwang@simm.ac.cn) ; Zhang, Tong(zhangtdmj@hotmail.com)
英文摘要Background: Gastric ulcer (GU) is the most common multifactor gastrointestinal disorder affecting millions of people worldwide. There is evidence that gut microbiota is closely related to the development of GU. Atractylone (ATR) has been reported to possess potential biological activities, but research on ATR alleviating GU injury is unprecedented.Methods: Helicobacter pylori (H. pylori)-induced GU model in zebrafish and ethanol-induced acute GU model in rat were established to evaluate the anti-inflammatory and ulcer inhibitory effects of ATR. Then, 16S rRNA sequencing and metabolomics analysis were performed to investigate the effect of ATR on the microbiota and metabolites in rat feces and their correlation.Results: Therapeutically, ATR inhibited H. pylori-induced gastric mucosal injury in zebrafish. In the ulceration model of rat, ATR mitigated the gastric lesions damage caused by ethanol, decreased the ulcer area, and reduced the production of inflammatory factors. Additionally, ATR alleviated the gastric oxidative stress injury by increasing the activity of superoxide dismutase (SOD) and decreasing the level of malondialdehyde (MDA). Furthermore, ATR played a positive role in relieving ulcer through reshaping gut microbiota composition including Parabacteroides and Bacteroides and regulating the levels of metabolites including amino acids, short-chain fatty acids (SCFAs), and bile acids.Conclusion: Our work sheded light on the mechanism of ATR treating GU from the perspective of the gut microbiota and explored the correlation between gut microbiota, metabolites, and host phenotype.
WOS关键词CHAIN FATTY-ACIDS ; IN-VITRO ; BUTYRATE ; ALPHA ; PHENYLALANINE ; INFLAMMATION ; ANTIOXIDANT ; TRYPTOPHAN ; ALCOHOL ; MICE
资助项目programs of the National Scientific and Technological Major Special Project of China[2019ZX09201004-002] ; programs of the National Scientific and Technological Major Special Project of China[2018ZX09721005-005] ; program of Shanghai Leading Talents[2019100] ; Shanghai University of Traditional Chinese Medicine[2020LK030] ; Key project of Shanghai 3-year plan[ZY (2018-2020) -CCCX-2001-04]
WOS研究方向Immunology
语种英语
WOS记录号WOS:000844855600001
出版者DOVE MEDICAL PRESS LTD
源URL[http://119.78.100.183/handle/2S10ELR8/302311]  
专题中国科学院上海药物研究所
通讯作者Wang, Bing; Zhang, Tong
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
2.Metabo Profile Biotechnol Shanghai Co Ltd, Shanghai, Peoples R China
3.Anhui Univ Chinese Med, Sch Pharm, Hefei, Peoples R China
4.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Li, Ling,Du, Yaoyao,Wang, Yang,et al. Atractylone Alleviates Ethanol-Induced Gastric Ulcer in Rat with Altered Gut Microbiota and Metabolites[J]. JOURNAL OF INFLAMMATION RESEARCH,2022,15:4709-4723.
APA Li, Ling,Du, Yaoyao,Wang, Yang,He, Ning,Wang, Bing,&Zhang, Tong.(2022).Atractylone Alleviates Ethanol-Induced Gastric Ulcer in Rat with Altered Gut Microbiota and Metabolites.JOURNAL OF INFLAMMATION RESEARCH,15,4709-4723.
MLA Li, Ling,et al."Atractylone Alleviates Ethanol-Induced Gastric Ulcer in Rat with Altered Gut Microbiota and Metabolites".JOURNAL OF INFLAMMATION RESEARCH 15(2022):4709-4723.

入库方式： OAI收割

来源：上海药物研究所

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