中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model

文献类型：期刊论文

作者Zhang, Longlong5,6; Zhu, Yuefei6; Wei, Xunbin3,4; Chen, Xing5,6; Li, Yang5,6; Zhu, Ying6; Xia, Jiaxuan6; Huang, Yiheng6; Huang, Yongzhuo2; Wang, Jianxin1,5,6
刊名ACTA PHARMACEUTICA SINICA B
出版日期2022-08-01
卷号12期号:8页码:3427-3447
关键词Nanoplateletsome Breast cancer Tumor metastasis Circulating tumor cells Nanodecoy Immunosuppressive micrometastatic environment Lung pre-metastasis
ISSN号2211-3835
DOI10.1016/j.apsb.2022.01.005
通讯作者Wang, Jianxin(jxwang@fudan.edu.cn) ; Pang, Zhiqing(zqpang@fudan.edu.cn)
英文摘要Platelets buoy up cancer metastasis via arresting cancer cells, enhancing their adhesion, and facilitating their extravasation through the vasculature. When deprived of intracellular and granular contents, platelet decoys could prevent metastatic tumor formation. Inspired by these, we developed nanoplatesomes by fusing platelet membranes with lipid membranes (P-Lipo) to restrain metastatic tumor formation more efficiently. It was shown nanoplateletsomes bound with circulating tumor cells (CTC) efficiently, interfered with CTC arrest by vessel endothelial cells, CTC extravasation through endothelial layers, and epithelial-mesenchymal transition of tumor cells as nanodecoys. More importantly, in the mouse breast tumor metastasis model, nanoplateletsomes could decrease CTC survival in the blood and counteract metastatic tumor growth efficiently by inhibiting the inflammation and suppressing CTC escape. Therefore, nanoplatelesomes might usher in a new avenue to suppress lung metastasis. (C) 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
WOS关键词DRUG-DELIVERY ; P-SELECTIN ; CELLS ; CANCER ; PLATELETS ; MEMBRANE ; NANOPARTICLES ; HEPARIN ; BLOOD ; INHIBITION
资助项目National Natural Science Foundation of China[81773283]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000842459600001
出版者INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
源URL[http://119.78.100.183/handle/2S10ELR8/302320]  
专题新药研究国家重点实验室
通讯作者Wang, Jianxin; Pang, Zhiqing
作者单位1.Fudan Univ, Acad Chinese & Western Integrat Med, Inst Mat Med, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200030, Peoples R China
4.Shanghai Jiao Tong Univ, Med X Res Inst, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai 200030, Peoples R China
5.Minist Educ, Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China
6.Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Longlong,Zhu, Yuefei,Wei, Xunbin,et al. Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model[J]. ACTA PHARMACEUTICA SINICA B,2022,12(8):3427-3447.
APA Zhang, Longlong.,Zhu, Yuefei.,Wei, Xunbin.,Chen, Xing.,Li, Yang.,...&Pang, Zhiqing.(2022).Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model.ACTA PHARMACEUTICA SINICA B,12(8),3427-3447.
MLA Zhang, Longlong,et al."Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model".ACTA PHARMACEUTICA SINICA B 12.8(2022):3427-3447.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。