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Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXV. Structurally diverse triterpenoids and diterpenoids from two endangered Pinaceae plants endemic to the Chinese Qinling Mountains and their bioactivities

文献类型：期刊论文

作者Jiang, Wei4,5,6; Zhao, Ze-Yu4,6; Tong, Ying-Peng6; Ma, Guang-Lei4; Zang, Yi3; Osman, Ezzat E. A.2,4; Jin, Ze-Xin6; Xiong, Juan4; Li, Jia3; Hu, Jin-Feng1,4,6
刊名PHYTOCHEMISTRY
出版日期2022-11-01
卷号203页码:14
关键词Picea neoveitchii Larix potaninii var. chinensis Pinaceae Endangered plants Terpenoids Neoveitchins Potalarxins PTP1B ACC1
ISSN号0031-9422
DOI10.1016/j.phytochem.2022.113366
通讯作者Xiong, Juan(jxiong@fudan.edu.cn) ; Hu, Jin-Feng(jfhu@tzc.edu.cn)
英文摘要A joint phytochemical investigation on the MeOH extracts of the twigs and needles of two endangered Pinaceae plants endemic to the Chinese Qinling Mountains, Picea neoveitchii (an evergreen spruce) and Larix potaninii var. chinensis (a deciduous larch), led to the isolation and characterization of 34 and 24 structurally diverse terpe-noids, respectively. Among them, seven are previously undescribed, including a picane-type [i.e., 14(13 -> 12) abeo-12aH-serratane] (neoveitchin A) and a serratane-type (neoveitchin B) triterpenoids, and an abietane-type (neoveitchin C) as well as four labdane-type (potalarxins A-D) diterpenoids. Their structures and absolute configurations were established by extensive spectroscopic methods and/or X-ray diffraction analyses. All iso-lates were evaluated for their inhibitory activities against the human protein tyrosine phosphatase 1B (PTP1B). Serrat-14-en-3a,21fl-diol, betulinic acid, 3fl-hydroxy-11-ursen-13(28)-olide, ursolic acid, and oleanolic acid were found to have considerable inhibitory effects against PTP1B, with IC50 values ranging from 1.1 to 18.1 mu M. The interactions of the bioactive triterpenoids with PTP1B were thereafter performed by employing molecular docking studies. In addition, 7-oxo-dehydroabietic acid (an abietane-type diterpenoid) and mangiferonic acid (a cycloartane-type triterpenoid) inhibited acetyl-coenzyme A carboxylase 1 (ACC1), with IC50 values of 3.4 and 6.6 mu M, respectively.
WOS关键词POTANINII VAR.-CHINENSIS ; CHEMICAL-CONSTITUENTS ; STEM BARK ; CONTACT ALLERGEN ; URSOLIC ACID ; IN-VITRO ; LEAVES ; BIOTRANSFORMATION ; TERPENOIDS ; INHIBITORS
资助项目NSFC[21937002] ; NSFC[81773599] ; NSFC[21772025]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:000843556300006
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/302323]  
专题新药研究国家重点实验室
通讯作者Xiong, Juan; Hu, Jin-Feng
作者单位1.Taizhou Univ, Zhejiang 318000, Peoples R China
2.Theodor Bilharz Res Inst, Dept Biochem Mol Biol & Med Chem, POB 30 Imbaba, Giza 12411, Egypt
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Fudan Univ, Sch Pharm, Dept Nat Med, Shanghai 201203, Peoples R China
5.Wuhan Polytech Univ, Sch Life Sci & Technol, Hubei 430023, Peoples R China
6.Taizhou Univ, Inst Nat Med & Hlth Prod, Sch Pharmaceut Sci, Zhejiang Prov Key Lab Plant Ecol & Conservat, Zhejiang 318000, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Wei,Zhao, Ze-Yu,Tong, Ying-Peng,et al. Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXV. Structurally diverse triterpenoids and diterpenoids from two endangered Pinaceae plants endemic to the Chinese Qinling Mountains and their bioactivities[J]. PHYTOCHEMISTRY,2022,203:14.
APA Jiang, Wei.,Zhao, Ze-Yu.,Tong, Ying-Peng.,Ma, Guang-Lei.,Zang, Yi.,...&Hu, Jin-Feng.(2022).Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXV. Structurally diverse triterpenoids and diterpenoids from two endangered Pinaceae plants endemic to the Chinese Qinling Mountains and their bioactivities.PHYTOCHEMISTRY,203,14.
MLA Jiang, Wei,et al."Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXV. Structurally diverse triterpenoids and diterpenoids from two endangered Pinaceae plants endemic to the Chinese Qinling Mountains and their bioactivities".PHYTOCHEMISTRY 203(2022):14.

入库方式： OAI收割

来源：上海药物研究所

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