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Spicatulides A-G, Phenolic-Monoterpenoid Hybrids from Chloranthus spicatus

文献类型：期刊论文

作者Zhou, Jun-Su3; Huang, Su-Ling3; Gao, Yuan3; Liu, Qun-Fang3; Leng, Ying3; Zhou, Bin2,3; Yue, Jian-Min1,2,3
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2022-08-26
卷号85期号:8页码:2090-2099
ISSN号0163-3864
DOI10.1021/acs.jnatprod.2c00546
通讯作者Zhou, Bin(zbbrush@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn)
英文摘要Spicatulides A-G (1-7), seven new phenolic- monoterpenoid hybrid molecules, along with two known compounds, 8 and 9, were isolated and identified from Chloranthus spicatus. Compound 1 represents an unprecedented skeleton featuring an aryl-fused 2-oxabicyclo[4.3.1]decane moiety, and compound 2 is the first example of a denudaquinol- normonoterpenoid adduct. Their structures with absolute configurations were elucidated on the basis of spectroscopic data analyses and TDDFT-ECD calculations. Compounds 3, 5, 6, and 9 exhibited the activity of reducing lipogenesis in HepG2 cells in a dose-dependent manner.
WOS关键词HOMOGENTISIC ACID-DERIVATIVES ; ELECTRONIC CIRCULAR-DICHROISM ; ENANTIOMERIC PAIRS ; MEROTERPENOIDS ; LEAVES ; AGENTS ; PHYTOCANNABINOIDS ; FRUITS
资助项目Shanghai Pujiang Program[21PJ1416000] ; Youth Innovation Promotion Association of CAS[2022283] ; National Natural Science Foundation[81861138045] ; CAMS Innovation Fund for Medical Sciences[2019-I2M-5-080] ; People?s Republic of China
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000841581200001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/302332]  
专题新药研究国家重点实验室
通讯作者Zhou, Bin; Yue, Jian-Min
作者单位1.Chinese Acad Med Sci, Res Units Discovery New Drug Lead Mol, Shanghai 201203, Peoples R China
2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Jun-Su,Huang, Su-Ling,Gao, Yuan,et al. Spicatulides A-G, Phenolic-Monoterpenoid Hybrids from Chloranthus spicatus[J]. JOURNAL OF NATURAL PRODUCTS,2022,85(8):2090-2099.
APA Zhou, Jun-Su.,Huang, Su-Ling.,Gao, Yuan.,Liu, Qun-Fang.,Leng, Ying.,...&Yue, Jian-Min.(2022).Spicatulides A-G, Phenolic-Monoterpenoid Hybrids from Chloranthus spicatus.JOURNAL OF NATURAL PRODUCTS,85(8),2090-2099.
MLA Zhou, Jun-Su,et al."Spicatulides A-G, Phenolic-Monoterpenoid Hybrids from Chloranthus spicatus".JOURNAL OF NATURAL PRODUCTS 85.8(2022):2090-2099.

入库方式： OAI收割

来源：上海药物研究所

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