MC1R and melanin-based molecular probes for theranostic of melanoma and beyond
文献类型：期刊论文
| 作者 | Shi, Hui3; Cheng, Zhen1,2,3 |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2022-08-25 |
| 页码 | 11 |
| 关键词 | melanoma molecular probes radiotracers MC1R melanin |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-022-00970-y |
| 通讯作者 | Cheng, Zhen(zcheng@simm.ac.cn) |
| 英文摘要 | Malignant melanoma is accounting for most of skin cancer-associated mortality. The incidence of melanoma increased every year worldwide especially in western countries. Treatment efficiency is highly related to the stage of melanoma. Therefore, accurate staging and restaging play a pivotal role in the management of melanoma patients. Though F-18-fluorodeoxyglucose (F-18-FDG) positron-emission tomography (PET) has been widely used in imaging of tumor metastases, novel radioactive probes for specific targeted imaging of both primary and metastasized melanoma are still desired. Melanocortin receptor 1 (MC1R) and melanin are two promising biomarkers specifically for melanoma, and numerous research groups including us have been actively developing a plethora of radioactive probes based on targeting of MC1R or melanin for over two decades. In this review, some of the MC1R-targeted tracers and melanin-associated molecular imaging probes developed in our research and others have been briefly summarized, and it provides a quick glance of melanoma-targeted probe design and may contribute to further developing novel molecular probes for cancer theranostics. |
| WOS关键词 | TARGETED RADIONUCLIDE THERAPY ; STIMULATING HORMONE ANALOG ; MALIGNANT-MELANOMA ; CUTANEOUS MELANOMA ; MELANOCORTIN-1 RECEPTOR ; ALPHA-MELANOTROPIN ; PEPTIDE ANALOG ; UNITED-STATES ; IN-VITRO ; FDG PET |
| 资助项目 | Shanghai Municipal Science and Technology Major Project |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000844585800001 |
| 出版者 | NATURE PUBL GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302344]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Cheng, Zhen |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Hui,Cheng, Zhen. MC1R and melanin-based molecular probes for theranostic of melanoma and beyond[J]. ACTA PHARMACOLOGICA SINICA,2022:11. |
| APA | Shi, Hui,&Cheng, Zhen.(2022).MC1R and melanin-based molecular probes for theranostic of melanoma and beyond.ACTA PHARMACOLOGICA SINICA,11. |
| MLA | Shi, Hui,et al."MC1R and melanin-based molecular probes for theranostic of melanoma and beyond".ACTA PHARMACOLOGICA SINICA (2022):11. |
入库方式： OAI收割
来源：上海药物研究所
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