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Cortex periplocae modulates the gut microbiota to restrict colitis and colitis-associated colorectal cancer via suppression of pathogenic Th17 cells

文献类型：期刊论文

作者Lin, Zemin3; Chen, Li2,3; Cheng, Mengnan3; Zhu, Fenghua3; Yang, Xiaoqian3; Zhao, Weimin1,2; Zuo, Jianping2,3; He, Shijun2,3
刊名BIOMEDICINE & PHARMACOTHERAPY
出版日期2022-09-01
卷号153页码:13
关键词Colitis Colitis -associated cancer Periploca sepium periplosides Gut microbiota Intestinal Type 17 immunity
ISSN号0753-3322
DOI10.1016/j.biopha.2022.113399
通讯作者Zuo, Jianping(jpzuo@simm.ac.cn) ; He, Shijun(heshijun@simm.ac.cn)
英文摘要Aberrant microbe-immune cell interaction is a predisposing factor in inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Cortex Periplocae is a famous traditional Chinese medicine with putative anti -rheumatoid arthritis and anti-dyspepsia effects. Here, we show that the Periploca sepium periplosides (PePs), a cardiac glycosides-free pregnane glycosides extract from root bark of Cortex Periplocae, alleviates colon inflammation, improves intestinal epithelial barrier function, and prevents colitis-associated tumorigenesis in mice with colitis and CAC. Mechanistically, PePs treatment modulates abnormal gut microbiota composition in model mice, especially enriches an anti-inflammatory commensal bacterium A. muciniphila BAA-835. We further demonstrate that the altered gut microbiota following PePs treatment plays an important role in modulation of intestinal Type 17 immunity in both colitis and CAC mouse model. Our results indicate that PePs may be used as a potential gut microbiota modulator to treat IBD and CAC.
WOS关键词PREGNANE GLYCOSIDES ; ROOT BARKS ; INFLAMMATION ; SEPIUM ; DIFFERENTIATION ; INDUCTION ; DISEASE ; IL-17A ; OIL
资助项目National Natural Science Foundation of China[81903882] ; National Natural Science Foundation of China[81871240] ; National Natural Science Foundation of China[22177123] ; Shanghai Municipal Science Technology Major Project ; Science and Technology Com- mission of Shanghai Municipality[21S11907700] ; Science and Technology Com- mission of Shanghai Municipality[21S11911000]
WOS研究方向Research & Experimental Medicine ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000839285900001
出版者ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/302350]  
专题新药研究国家重点实验室
通讯作者Zuo, Jianping; He, Shijun
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Res Ctr, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Lin, Zemin,Chen, Li,Cheng, Mengnan,et al. Cortex periplocae modulates the gut microbiota to restrict colitis and colitis-associated colorectal cancer via suppression of pathogenic Th17 cells[J]. BIOMEDICINE & PHARMACOTHERAPY,2022,153:13.
APA Lin, Zemin.,Chen, Li.,Cheng, Mengnan.,Zhu, Fenghua.,Yang, Xiaoqian.,...&He, Shijun.(2022).Cortex periplocae modulates the gut microbiota to restrict colitis and colitis-associated colorectal cancer via suppression of pathogenic Th17 cells.BIOMEDICINE & PHARMACOTHERAPY,153,13.
MLA Lin, Zemin,et al."Cortex periplocae modulates the gut microbiota to restrict colitis and colitis-associated colorectal cancer via suppression of pathogenic Th17 cells".BIOMEDICINE & PHARMACOTHERAPY 153(2022):13.

入库方式： OAI收割

来源：上海药物研究所

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