A Novel High-Sensitivity Terahertz Microstructure Fiber Biosensor for Detecting Cancer Cells
文献类型:期刊论文
作者 | Zhang, Yani3; Miao, Ting3; Mu, Qiyuan2; Zhou, Lei1; Meng, Cheng1; Xue, Jia3; Yao, Yiming3 |
刊名 | PHOTONICS |
出版日期 | 2022-09 |
卷号 | 9期号:9 |
ISSN号 | 2304-6732 |
关键词 | cancer cells terahertz microstructure fiber finite element method sensitivity effective material loss |
DOI | 10.3390/photonics9090639 |
产权排序 | 2 |
英文摘要 | Cancer is one of the leading causes of mortality worldwide. In recent years, various kinds of biosensors based on optical fiber have been proposed for detection of cancer cells due to their advantages of accurate diagnosis, small size, low cost, and flexible design parameters. In the present study, a microstructure fiber (MSF) biosensor with porous-core structures was designed to detect cancer cells using a terahertz time-domain system (TDS). The fiber characteristics of the proposed MSF were optimized by adopting a finite element numerical technique and perfectly matching layer absorption boundary conditions. The numerical results show that the proposed biosensor presented an ultrahigh sensitivity for detection of cancer cells. Under the optimal condition of 0.9 THz, the relative sensitivity of the proposed structure to breast cancer cells was as high as 99.8%. Moreover, other optical fiber parameters, such as effective material loss (EML), confinement loss (CL), numerical aperture (NA), power fraction, and effective area (A(eff)), were optimal according to the reported results. The proposed structure can be easily fabricated by 3D printing and flexibly applied in the fields of biomedicine and biosensing with a terahertz (THz) waveguide. |
语种 | 英语 |
出版者 | MDPI |
WOS记录号 | WOS:000858797800001 |
源URL | [http://ir.opt.ac.cn/handle/181661/96153] |
专题 | 西安光学精密机械研究所_先进光电与生物材料研发中心 |
通讯作者 | Zhang, Yani |
作者单位 | 1.Shaanxi Univ Sci & Technol, Sch Elect & Control Engn, Xian 710021, Peoples R China 2.Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Xian 710119, Peoples R China 3.Univ Sci & Technol, Sch Arts & Sci, Dept Phys, Xian 710021, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Yani,Miao, Ting,Mu, Qiyuan,et al. A Novel High-Sensitivity Terahertz Microstructure Fiber Biosensor for Detecting Cancer Cells[J]. PHOTONICS,2022,9(9). |
APA | Zhang, Yani.,Miao, Ting.,Mu, Qiyuan.,Zhou, Lei.,Meng, Cheng.,...&Yao, Yiming.(2022).A Novel High-Sensitivity Terahertz Microstructure Fiber Biosensor for Detecting Cancer Cells.PHOTONICS,9(9). |
MLA | Zhang, Yani,et al."A Novel High-Sensitivity Terahertz Microstructure Fiber Biosensor for Detecting Cancer Cells".PHOTONICS 9.9(2022). |
入库方式: OAI收割
来源:西安光学精密机械研究所
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