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Could Environment Affect the Mutation of H1N1 Influenza Virus?

文献类型：期刊论文

作者Jiang, Dong1,2; Wang, Qian1,2; Bai, Zhihua2,3; Qi, Heyuan3; Ma, Juncai3; Liu, Wenjun2,3,4,5; Ding, Fangyu1,3; Li, Jing2,3
刊名INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
出版日期2020-05-01
卷号17期号:9页码:9
关键词H1N1 influenza virus mutation environment factors
DOI10.3390/ijerph17093092
通讯作者Ding, Fangyu(dingfy.17b@igsnrr.ac.cn) ; Li, Jing(lj418@163.com)
英文摘要H1N1 subtype influenza A viruses are the most common type of influenza A virus to infect humans. The two major outbreaks of the virus in 1918 and 2009 had a great impact both on human health and social development. Though data on their complete genome sequences have recently been obtained, the evolution and mutation of A/H1N1 viruses remain unknown to this day. Among many drivers, the impact of environmental factors on mutation is a novel hypothesis worth studying. Here, a geographically disaggregated method was used to explore the relationship between environmental factors and mutation of A/H1N1 viruses from 2000-2019. All of the 11,721 geo-located cases were examined and the data was analysed of six environmental elements according to the time and location (latitude and longitude) of those cases. The main mutation value was obtained by comparing the sequence of the influenza virus strain with the earliest reported sequence. It was found that environmental factors systematically affect the mutation of A/H1N1 viruses. Minimum temperature displayed a nonlinear, rising association with mutation, with a maximum similar to 15 degrees C. The effects of precipitation and social development index (nighttime light) were more complex, while population density was linearly and positively correlated with mutation of A/H1N1 viruses. Our results provide novel insight into understanding the complex relationships between mutation of A/H1N1 viruses and environmental factors.
WOS关键词CLIMATE-CHANGE ; EVOLUTION ; INFECTION ; DIVERSITY ; TRENDS
资助项目Mega-Project of Guangxi Natural Science Foundation[2015GXNSFEA139002] ; National Natural Science Foundation of China[31970153] ; National Natural Science Foundation of China[31630079] ; National Key R&D Program of China[2016YFD0500206] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29010000] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA19040305] ; Youth Innovation Promotion Association of CAS[2019091]
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
语种英语
WOS记录号WOS:000535745400116
出版者MDPI
资助机构Mega-Project of Guangxi Natural Science Foundation ; National Natural Science Foundation of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of CAS
源URL[http://ir.igsnrr.ac.cn/handle/311030/159564]  
专题中国科学院地理科学与资源研究所
通讯作者Ding, Fangyu; Li, Jing
作者单位1.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
4.Guangxi Univ, Coll Anim Sci & Vet Med, State Key Lab Conservat & Utilizat Subtrop Agrobi, Nanning 530004, Guangxi, Peoples R China
5.Guangxi Univ, Coll Anim Sci & Vet Med, Lab Anim Infect Dis, Nanning 530004, Guangxi, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Dong,Wang, Qian,Bai, Zhihua,et al. Could Environment Affect the Mutation of H1N1 Influenza Virus?[J]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH,2020,17(9):9.
APA Jiang, Dong.,Wang, Qian.,Bai, Zhihua.,Qi, Heyuan.,Ma, Juncai.,...&Li, Jing.(2020).Could Environment Affect the Mutation of H1N1 Influenza Virus?.INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH,17(9),9.
MLA Jiang, Dong,et al."Could Environment Affect the Mutation of H1N1 Influenza Virus?".INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 17.9(2020):9.

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来源：地理科学与资源研究所

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