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Investigating potential associations between O3 exposure and lipid profiles: A longitudinal study of older adults in Beijing

文献类型：期刊论文

作者Li, Ang3,4; Pei, Lu3,4; Zhao, Meiduo3,4; Xu, Jing3,4; Mei, Yayuan3,4; Li, Runkui1,2; Xu, Qun3,4
刊名ENVIRONMENT INTERNATIONAL
出版日期2019-12-01
卷号133页码:12
关键词Ozone Lipid profile Lipid indices Dyslipidemia Effect modification
ISSN号0160-4120
DOI10.1016/j.envint.2019.105135
英文摘要Background: Little information exists on the lipidemic effects of ozone exposure. Few studies have focused on the different patterns of the association among older adults population, and little attention has been given to comprehensive lipid indices when evaluating the effect of O-3 exposure on the metabolism. Methods: We conducted a longitudinal study involving 201 older adults in Beijing, China between 2016 and 2018. A mixed regression model was applied with random effects to investigate the relationship between O-3 and lipid profiles. Results: O-3 exposure positively correlated with TC, LDL-C, CRI-I, CRI-II and AC at short-term and medium-term exposure periods. The largest increases in TC, LDL-C, CRI-I and CRI-II were found in the 28-days moving average indicating accumulative effects over prolonged exposure period. A 10 mu g/m(3) increase of O-3 at the 28-days moving average was associated with a significant increase of 3.9% (95% CI: 1.0, 6.9) in TC, 8.2% (95% CI: 4.2, 12.4) in LDL-C, 4.8% (95% CI: 1.1, 8.5) in CRI-I and 7.0% (95% CI: 2.7, 11.5) in CRI-II. Stratification by health status and characteristics revealed different patterns of lipid changes among older adults, lipid status, age, sex and BMI may modify the relationship between O-3 exposure and lipid profiles. Conclusions: Our findings suggest that short-term and medium-term O-3 exposure is associated with lipid profiles abnormalities among the older adults. Evidence also suggests there are patterns within population which differ according to both health status and demographic characteristics.
WOS关键词DENSITY-LIPOPROTEIN CHOLESTEROL ; CORONARY-HEART-DISEASE ; AMBIENT AIR-POLLUTION ; SHORT-TERM EXPOSURE ; OZONE EXPOSURE ; BLOOD-LIPIDS ; CARDIOVASCULAR RISK ; PHYSICAL-ACTIVITY ; OXIDATIVE STRESS ; PLASMA
资助项目China Medical Board[15-230] ; China Prospective cohort study of Air pollution and health effects in Typical areas (C-PAT)[MEE-EH-20190802] ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences[3332019147] ; National Key Research and Development Program of China[2017YFB0503605] ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences[2017-I2M-1-009] ; Program of Science and Technology Service Network Initiative (STS) of Chinese Academy of Sciences[Y88Q0300YD] ; National Natural Science Foundation of China[41771435] ; China Scholarship Council[201704910297]
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000498895700010
出版者PERGAMON-ELSEVIER SCIENCE LTD
资助机构China Medical Board ; China Prospective cohort study of Air pollution and health effects in Typical areas (C-PAT) ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences ; National Key Research and Development Program of China ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences ; Program of Science and Technology Service Network Initiative (STS) of Chinese Academy of Sciences ; National Natural Science Foundation of China ; China Scholarship Council
源URL[http://ir.igsnrr.ac.cn/handle/311030/130057]  
专题资源与环境信息系统国家重点实验室_外文论文
作者单位1.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
3.Chinese Acad Med Sci, Peking Union Med Coll, Ctr Environm & Hlth Sci, Beijing 100005, Peoples R China
4.Chinese Acad Med Sci, Peking Union Med Coll, Sch Basic Med, Dept Epidemiol & Biostat,Inst Basic Med Sci, Beijing 100005, Peoples R China
推荐引用方式
GB/T 7714		 Li, Ang,Pei, Lu,Zhao, Meiduo,et al. Investigating potential associations between O3 exposure and lipid profiles: A longitudinal study of older adults in Beijing[J]. ENVIRONMENT INTERNATIONAL,2019,133:12.
APA Li, Ang.,Pei, Lu.,Zhao, Meiduo.,Xu, Jing.,Mei, Yayuan.,...&Xu, Qun.(2019).Investigating potential associations between O3 exposure and lipid profiles: A longitudinal study of older adults in Beijing.ENVIRONMENT INTERNATIONAL,133,12.
MLA Li, Ang,et al."Investigating potential associations between O3 exposure and lipid profiles: A longitudinal study of older adults in Beijing".ENVIRONMENT INTERNATIONAL 133(2019):12.

入库方式： OAI收割

来源：地理科学与资源研究所

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