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Experimental study of a heparin-coated venous stent fabricated by atomic layer deposition

文献类型：期刊论文

作者Li, Xiaoying5; Zhang, Kunpeng4; Jiang, Xiaorui4; Wang, Lei3; Zhang, Tao2; Zhang, Xiaoming1; Che, Haijie4
刊名JOURNAL OF BIOMATERIALS APPLICATIONS
出版日期2022-09-23
页码11
ISSN号0885-3282
关键词venous stent heparin-coated experimental study atomic layer deposition technology vascular endothelialization endovascular stent surface modification
DOI10.1177/08853282221126575
通讯作者Che, Haijie(chj1437@163.com)
英文摘要Objective To evaluate the safety and efficacy of heparin-coated venous stents in animals. Methods We used atomic layer deposition technology to obtain a heparin coating with good stability and then prepared a heparin-coated venous stent based on this technology. The experimental stents were prepared according to the diameter of the rabbit inferior vena cava and were divided into Ni-Ti alloy stent group, Ni-Ti-Al2O3 stent group and Ni-Ti-Al2O3-Heparin stent group. 3 days, 7 days and 14 days after stent implantation, the materials were collected, and the three groups of stents were observed by hard tissue section pathology, immunohistochemistry and scanning electron microscope to observe the differences in vascular wall inflammation, thrombosis, lumen stenosis and vascular intima regeneration. Result and Conclusion The experiment confirmed the safety of the heparin-coated stent in vivo. Compared with the control group, the experimental group showed a high degree of vascular endothelialization and an intact neointimal structure 14 days after implantation. The long-term safety and biological effects of heparin-coated venous stents in animals require further study.
WOS关键词TRANSLUMINAL CORONARY ANGIOPLASTY ; ELASTIC RECOIL ; RESTENOSIS ; BIOFUNCTIONALIZATION ; ENDOTHELIALIZATION ; SULFATE ; CELLS ; MODEL
WOS研究方向Engineering ; Materials Science
语种英语
WOS记录号WOS:000860933900001
资助机构Shandong Province Major Science and Technology Innovation Project
源URL[http://ir.yic.ac.cn/handle/133337/31721]  
专题烟台海岸带研究所_中科院烟台海岸带研究所知识产出
通讯作者Che, Haijie
作者单位1.Peking Univ Peoples Hosp, Beijing, Peoples R China
2.Nanjing Univ, Nanjing, Peoples R China
3.Yantai Inst Coastal Zone Res, Yantai, Peoples R China
4.Qingdao Univ, YanTai Yuhuangding Hosp, 20 Yuhuangding East Rd, Yantai 264000, Peoples R China
5.Yantai Qishan Hosp, Yantai, Peoples R China
推荐引用方式
GB/T 7714		 Li, Xiaoying,Zhang, Kunpeng,Jiang, Xiaorui,et al. Experimental study of a heparin-coated venous stent fabricated by atomic layer deposition[J]. JOURNAL OF BIOMATERIALS APPLICATIONS,2022:11.
APA Li, Xiaoying.,Zhang, Kunpeng.,Jiang, Xiaorui.,Wang, Lei.,Zhang, Tao.,...&Che, Haijie.(2022).Experimental study of a heparin-coated venous stent fabricated by atomic layer deposition.JOURNAL OF BIOMATERIALS APPLICATIONS,11.
MLA Li, Xiaoying,et al."Experimental study of a heparin-coated venous stent fabricated by atomic layer deposition".JOURNAL OF BIOMATERIALS APPLICATIONS (2022):11.

入库方式： OAI收割

来源：烟台海岸带研究所

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