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Self-luminescent europium based metal organic frameworks nanorods as a novel electrochemiluminescence chromophore for sensitive ulinastatin detection in biological samples

文献类型：期刊论文

作者Li, Xin2; Zhao, Yuqing2; Hao, Xiaowen2; Wang, Xiaobin2; Luan, Feng2; Tian, Chunyuan2; Zhang, Zhiyang1; Yu, Shunyang1; Zhuang, Xuming2
刊名TALANTA
出版日期2022-12-01
卷号250页码:8
ISSN号0039-9140
关键词Ulinastatin Electrochemiluminescence Metal organic frameworks Self-luminescent Immunoassay
DOI10.1016/j.talanta.2022.123726
通讯作者Yu, Shunyang(syyu@yic.ac.cn) ; Zhuang, Xuming(xmzhuang@iccas.ac.cn)
英文摘要In this work, we developed a novel electrochemiluminescence (ECL) biosensor for ulinastatin (UTI) detection based on self-luminescent metal-organic framework (L-MOF) nanomaterials. The L-MOFs could be simply pre -pared by one-pot methods using Eu3+ and 4,4 ',4 ''-s-triazine-1,3,5-triyltri-m-aminobenzoic acid (H(3)TATAB) as the metallic center and organic ligand, respectively. The Eu-TATAB exhibited high efficiency and stable ECL performance when using K2S2O8 as coreactant. For the established biosensor, Eu-TATAB was both used as the ECL chromophore and protein carrier due to its outstanding biocompatibility and large superficial area, which could load sufficient antibodies to link with antigen in the biosensor for subsequent detection. The established sandwich ECL biosensor showed a wide linear range of 0.1 ng mL(-1) - 10(5) ng mL(-1) and a low limit of detection of 9.7 pg mL(-1 )for UTI detection. In addition, the developed ECL biosensor could also be successfully applied to the real UTI sample determination in serum. The reported biosensor strategy could provide a guide for developing more other novel and promising high-performance ECL nanomaterials, and also be used as a potential method for ultrasensitive UTI detection in disease research.
WOS关键词ELECTROGENERATED CHEMILUMINESCENCE ; MOF
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000829235400008
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province ; Scientific Instru- ment Developing Project of the Chinese Academy of Sciences ; Key Science and Technology Program of Yantai
源URL[http://ir.yic.ac.cn/handle/133337/31615]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Yu, Shunyang; Zhuang, Xuming
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China
2.Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China
推荐引用方式
GB/T 7714		 Li, Xin,Zhao, Yuqing,Hao, Xiaowen,et al. Self-luminescent europium based metal organic frameworks nanorods as a novel electrochemiluminescence chromophore for sensitive ulinastatin detection in biological samples[J]. TALANTA,2022,250:8.
APA Li, Xin.,Zhao, Yuqing.,Hao, Xiaowen.,Wang, Xiaobin.,Luan, Feng.,...&Zhuang, Xuming.(2022).Self-luminescent europium based metal organic frameworks nanorods as a novel electrochemiluminescence chromophore for sensitive ulinastatin detection in biological samples.TALANTA,250,8.
MLA Li, Xin,et al."Self-luminescent europium based metal organic frameworks nanorods as a novel electrochemiluminescence chromophore for sensitive ulinastatin detection in biological samples".TALANTA 250(2022):8.

入库方式： OAI收割

来源：烟台海岸带研究所

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