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Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination

文献类型：期刊论文

作者Arabi, Maryam4; Ostovan, Abbas4; Wang, Yunqing3,4; Mei, Rongchao4; Fu, Longwen4; Li, Jinhua4; Wang, Xiaoyan2,4; Chen, Lingxin1,3,4
刊名NATURE COMMUNICATIONS
出版日期2022-09-30
卷号13期号:1页码:14
DOI10.1038/s41467-022-33448-w
通讯作者Wang, Yunqing(yqwang@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要Chiral discrimination is critical in environmental and life sciences. However, an ideal chiral discrimination strategy has not yet been developed because of the inevitable nonspecific binding entity of wrong enantiomers or insufficient intrinsic optical activities of chiral molecules. Here, we propose an "inspector" recognition mechanism (IRM), which is implemented on a chiral imprinted polydopamine (PDA) layer coated on surface-enhanced Raman scattering (SERS) tag layer. The IRM works based on the permeability change of the imprinted PDA after the chiral recognition and scrutiny of the permeability by an inspector molecule. Good enantiomer can specifically recognize and fully fill the chiral imprinted cavities, whereas the wrong cannot. Then a linear shape aminothiol molecule, as an inspector of the recognition status is introduced, which can only percolate through the vacant and nonspecifically occupied cavities, inducing the SERS signal to decrease. Accordingly, chirality information exclusively stems from good enantiomer specific binding, while nonspecific recognition of wrong enantiomer is curbed. The IRM benefits from sensitivity and versatility, enabling absolute discrimination of a wide variety of chiral molecules regardless of size, functional groups, polarities, optical activities, Raman scattering, and the number of chiral centers.
WOS关键词POLYMERS ; PERSPECTIVES
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000862415000025
资助机构Chinese Academy of Sciences President's International Fellowship Initiative ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Instrument Developing Project of the Chinese Academy of Sciences ; Technical Innovation Project of Instrument Function Development of the Chinese Academy of Sciences ; Taishan Scholar Project
源URL[http://ir.yic.ac.cn/handle/133337/31751]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Wang, Yunqing; Chen, Lingxin
作者单位1.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
2.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Arabi, Maryam,Ostovan, Abbas,Wang, Yunqing,et al. Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination[J]. NATURE COMMUNICATIONS,2022,13(1):14.
APA Arabi, Maryam.,Ostovan, Abbas.,Wang, Yunqing.,Mei, Rongchao.,Fu, Longwen.,...&Chen, Lingxin.(2022).Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination.NATURE COMMUNICATIONS,13(1),14.
MLA Arabi, Maryam,et al."Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination".NATURE COMMUNICATIONS 13.1(2022):14.

入库方式： OAI收割

来源：烟台海岸带研究所

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