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Synthesis, Characterization, and the Antioxidant Activity of Phenolic Acid Chitooligosaccharide Derivatives

文献类型：期刊论文

作者Sun, Yan2,3; Ji, Xia1; Cui, Jingmin2,3; Mi, Yingqi2,3; Zhang, Jingjing2,3; Guo, Zhanyong2,3
刊名MARINE DRUGS
出版日期2022-08-01
卷号20期号:8页码:16
关键词chitooligosaccharide derivatives phenolic acid antioxidant activity
DOI10.3390/md20080489
通讯作者Ji, Xia(jixia@qlmu.edu.cn) ; Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要A series of phenolic acid chitooligosaccharide (COS) derivatives synthesized by two mild and green methods were illuminated in this paper. Seven phenolic acids were selected to combine two kinds of COS derivatives: the phenolic acid chitooligosaccharide salt derivatives and the phenolic-acid-acylated chitooligosaccharide derivatives. The structures of the derivatives were characterized by FT-IR and H-1 NMR spectra. The antioxidant experiment results in vitro (including DPPH-radical scavenging activity, superoxide-radical scavenging activity, hydroxyl-radical scavenging ability, and reducing power) demonstrated that the derivatives exhibited significantly enhanced antioxidant activity compared to COS. Moreover, the study showed that the phenolic acid chitooligosaccharide salts had stronger antioxidant activity than phenolic-acid-acylated chitooligosaccharide. The cytotoxicity assay of L929 cells in vitro indicated that the derivatives had low cytotoxicity and good biocompatibility. In conclusion, this study provides a possible synthetic method for developing novel and nontoxic antioxidant agents which can be used in the food and cosmetics industry.
WOS关键词FUNCTIONALIZED CHITOSAN DERIVATIVES ; FREE-RADICALS ; FLAVONOIDS ; HEALTH
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000845534400001
资助机构Key Deployment Project of Center for Ocean Mega-Science of CAS ; Natural Science Foundation of Shandong Province of China ; 2020 annual Special Research Assistant Project of Chinese Academy of Sciences and Youth Innovation Promotion Association CAS
源URL[http://ir.yic.ac.cn/handle/133337/31646]  
专题海岸带生物学与生物资源利用重点实验室
海岸带生物资源高效利用研究与发展中心
通讯作者Ji, Xia; Guo, Zhanyong
作者单位1.Qilu Med Univ, Sch Pharm, Zibo 255300, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Yan,Ji, Xia,Cui, Jingmin,et al. Synthesis, Characterization, and the Antioxidant Activity of Phenolic Acid Chitooligosaccharide Derivatives[J]. MARINE DRUGS,2022,20(8):16.
APA Sun, Yan,Ji, Xia,Cui, Jingmin,Mi, Yingqi,Zhang, Jingjing,&Guo, Zhanyong.(2022).Synthesis, Characterization, and the Antioxidant Activity of Phenolic Acid Chitooligosaccharide Derivatives.MARINE DRUGS,20(8),16.
MLA Sun, Yan,et al."Synthesis, Characterization, and the Antioxidant Activity of Phenolic Acid Chitooligosaccharide Derivatives".MARINE DRUGS 20.8(2022):16.

入库方式： OAI收割

来源：烟台海岸带研究所

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