Preparation of chitosan-rosmarinic acid derivatives with enhanced antioxidant and anti-inflammatory activities
文献类型:期刊论文
作者 | Zhang, Jingjing3; Wang, Linqing2; Tan, Wenqiang3; Li, Qing3; Dong, Fang3; Guo, Zhanyong1,3 |
刊名 | CARBOHYDRATE POLYMERS |
出版日期 | 2022-11-15 |
卷号 | 296页码:14 |
ISSN号 | 0144-8617 |
关键词 | Antioxidant activity Anti-inflammatory activity Chitosan derivatives Rosmarinic acid Structural characterization |
DOI | 10.1016/j.carbpol.2022.119943 |
通讯作者 | Guo, Zhanyong(zhanyongguo@hotmail.com) |
英文摘要 | In present study, several chitosan derivatives grafted with rosmarinic acid,including chitosan-rosmarinic acid conjugate (CS-RA), chitosan rosmarinic acid salt (CSRA), N,N,N-trimethylated chitosan rosmarinic acid salt (TMCRA), and N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan rosmarinic acid salt (HACRA), were prepared and the effects of different grafting methods on bioactivity of these derivatives were investigated. The structural characterization was identified by FTIR and H-1 NMR spectroscopy. The chitosan derivatives were also evaluated biologically for antioxidant, cytotoxic, and anti-inflammatory activities. Derivatives CSRA, TMCRA, and HACRA prepared through ion exchange method exhibited significant antioxidant ability. All derivatives remarkably inhibited lipopolysaccharide-induced nitric oxide and TNF-alpha production in RAW 264.7 cells without cytotoxicity, especially derivative TMCRA, whose inhibition rate was > 50 % at only 250 mu g/mL. The results suggested that chitosan quaternary ammonium derivatives grafted with rosmarinic acid possessed better anti-oxidant and anti-inflammatory properties than chitosan, which could be used as drug materials against oxidative and inflammation-related pathological processes. |
WOS关键词 | IONS ; TOOL |
WOS研究方向 | Chemistry ; Polymer Science |
语种 | 英语 |
WOS记录号 | WOS:000860980900001 |
资助机构 | National Key Research and Development Program of China ; Natural Science Foundation of Shandong Province of China ; Youth Innovation Promotion Association CAS ; Chinese Academy of Sciences |
源URL | [http://ir.yic.ac.cn/handle/133337/31718] |
专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
通讯作者 | Guo, Zhanyong |
作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Ludong Univ, Sch Chem & Mat Sci, Yantai 264025, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Jingjing,Wang, Linqing,Tan, Wenqiang,et al. Preparation of chitosan-rosmarinic acid derivatives with enhanced antioxidant and anti-inflammatory activities[J]. CARBOHYDRATE POLYMERS,2022,296:14. |
APA | Zhang, Jingjing,Wang, Linqing,Tan, Wenqiang,Li, Qing,Dong, Fang,&Guo, Zhanyong.(2022).Preparation of chitosan-rosmarinic acid derivatives with enhanced antioxidant and anti-inflammatory activities.CARBOHYDRATE POLYMERS,296,14. |
MLA | Zhang, Jingjing,et al."Preparation of chitosan-rosmarinic acid derivatives with enhanced antioxidant and anti-inflammatory activities".CARBOHYDRATE POLYMERS 296(2022):14. |
入库方式: OAI收割
来源:烟台海岸带研究所
浏览0
下载0
收藏0
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。