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Investigation into the content change and distribution of active components in Cordyceps sinensis with growth cycle by direct TOF-SIMS detection

文献类型：期刊论文

作者Xia, Meng-Chan1; Zhan, Qin3,5; Cai, Lesi4; Wu, Jiang3; Yang, Lu4; Sun, Suqin4; Liang, Handong3; Li, Zhanping2,4
刊名MICROCHEMICAL JOURNAL
出版日期2021-05-01
卷号164页码:5
关键词TOF-SIMS Cordyceps sinensis Active components Content change Growth cycle
ISSN号0026-265X
DOI10.1016/j.microc.2021.106026
通讯作者Cai, Lesi(cls15@mails.tsinghua.edu.cn) ; Liang, Handong(hdl6688@vip.sina.com) ; Li, Zhanping(zhanpingli@mail.tsinghua.edu.cn)
英文摘要Analyzing the content of active components in Chinese medicines is crucial to evaluate their medicinal value and further promote the development of pharmaceutical technology. In this work, Cordyceps sinensis, a precious Chinese medicine, was characterized by time-of-flight secondary ion mass spectrometry (TOF-SIMS) to measure the content change of amino acids, nucleosides, mannitol and ergosterol with its growth cycle. Direct and sensitive detection of these active components in Cordyceps sinensis was realized by TOF-SIMS without tedious pretreatment process, such as repeated extraction and purification. Due to complex metabolic regulation, amino acids, nucleosides, mannitol and ergosterol showed different changing trends with growth cycle of Cordyceps sinensis. We found that the changing trend of the same active substance in different parts of Cordyceps sinensis varied dramatically. For instance, with the growth cycle of Cordyceps sinensis, the content of mannitol maintained steady growth in the stroma, while fell first and rose later in the worm body. In some growth stage, the content of mannitol in the worm body was about 10 times higher than that in the stroma. We provided a systematically analytical method and rich data base for further research of the extraction of active components and artificial cultivation of Cordyceps sinensis in this study. Meanwhile, TOF-SIMS is verified to be a sensitive, efficient and convenient method to characterize active components in traditional Chinese medicines.
资助项目National Key R&D Program of China[2018YFA0702600]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000635089400006
出版者ELSEVIER
资助机构National Key R&D Program of China
源URL[http://ir.igsnrr.ac.cn/handle/311030/161836]  
专题中国科学院地理科学与资源研究所
通讯作者Cai, Lesi; Liang, Handong; Li, Zhanping
作者单位1.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China
2.Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China
3.China Univ Min & Technol, Sch Chem & Environm Engn, Beijing 100083, Peoples R China
4.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
5.Guzhen Cty 1 Middle Sch, Bengbu 233700, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Xia, Meng-Chan,Zhan, Qin,Cai, Lesi,et al. Investigation into the content change and distribution of active components in Cordyceps sinensis with growth cycle by direct TOF-SIMS detection[J]. MICROCHEMICAL JOURNAL,2021,164:5.
APA Xia, Meng-Chan.,Zhan, Qin.,Cai, Lesi.,Wu, Jiang.,Yang, Lu.,...&Li, Zhanping.(2021).Investigation into the content change and distribution of active components in Cordyceps sinensis with growth cycle by direct TOF-SIMS detection.MICROCHEMICAL JOURNAL,164,5.
MLA Xia, Meng-Chan,et al."Investigation into the content change and distribution of active components in Cordyceps sinensis with growth cycle by direct TOF-SIMS detection".MICROCHEMICAL JOURNAL 164(2021):5.

入库方式： OAI收割

来源：地理科学与资源研究所

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