Associations between blood heavy metal(loid)s and serum heme oxygenase-1 in pregnant women: Do their distribution patterns matter?
文献类型：期刊论文
| 作者 | Li, Kexin2; Wang, Bin1,3; Yan, Lailai4; Jin, Yu1,3; Li, Zhiyi2; An, Hang1,3; Ren, Mengyuan1,3; Pang, Yiming1,3; Lan, Changxin1,3; Chen, Junxi1,3 |
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2021-10-01 |
| 卷号 | 286页码:7 |
| ISSN号 | 0269-7491 |
| 关键词 | Heavy metals Serum Blood cells Oxidative stress Distribution pattern |
| DOI | 10.1016/j.envpol.2021.117249 |
| 通讯作者 | Wang, Bin(binwangpku@foxmail.com) |
| 英文摘要 | The relationship between heavy metal(loid)s exposure and oxidative stress damage is a matter of research interest. Our study aimed to investigate the distribution patterns of the nine heavy metal(loid)s in blood of pregnant women, including four toxic heavy metal(loid)s [arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg)] and five typical heavy metal(loid)s [manganese (Mn), cobalt (Co), copper (Cu), zinc (Zn), and selenium (Se)] in blood. Blood samples of 348 women were collected and their concentrations in the serum (sr) and blood cells (bc) were measured, as well as serum heme oxygenase-1 (HO-1) (an oxidative stress marker). Total blood (tb) concentrations of these metal(loid)s and serum-to-blood cell concentration ratios (sr/bc) were further calculated. We found Cu mainly accumulated in the serum compared to the blood cells with Cu-sr/bc = 2.30, whereas Co, Se, and As evenly distributed between these two fractions. Other metal(loid)s mainly concentrated in the blood cells. Co-sr, Cu-sr, Cu-bc, Mn-bc, Zn-bc, Cd-bc, Co-tb, Cu-tb, Mn-tb, Zn-tb, Cd-tb, and Cu-sr/bc were negatively associated with serum HO-1, whereas As-sr, As-bc, As-tb, Zn-sr/bc, Cd-sr/bc, and Hg-sr/bc were positively, indicating of their potential toxicity. We concluded that the distribution patterns of blood heavy metal(loid)s, in particular for Cd, Hg and Zn, which either increased in serum or decreased in blood cells, might be associated with elevated serum oxidative stress, should be considered in environmental health assessments. |
| WOS关键词 | WHOLE-BLOOD ; OXIDATIVE STRESS ; ANTIOXIDANT ENZYMES ; TRACE-ELEMENTS ; METHYL MERCURY ; METALS ; POPULATION ; SELENIUM ; PLASMA ; CADMIUM |
| 资助项目 | National Natural Science Foundation of China[41771527] ; National Natural Science Foundation of China[81673177] ; National Natural Science Foundation of China[42077390] |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000687470800001 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/165153]  |
| 专题 | 中国科学院地理科学与资源研究所 |
| 通讯作者 | Wang, Bin |
| 作者单位 | 1.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China 2.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China 3.Peking Univ, Key Lab Reprod Hlth, Inst Reprod & Child Hlth, Natl Hlth Commiss Peoples Republ China, Beijing 100191, Peoples R China 4.Peking Univ, Sch Publ Hlth, Dept Laboratorial Sci & Technol, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Kexin,Wang, Bin,Yan, Lailai,et al. Associations between blood heavy metal(loid)s and serum heme oxygenase-1 in pregnant women: Do their distribution patterns matter?[J]. ENVIRONMENTAL POLLUTION,2021,286:7. |
| APA | Li, Kexin.,Wang, Bin.,Yan, Lailai.,Jin, Yu.,Li, Zhiyi.,...&Ren, Aiguo.(2021).Associations between blood heavy metal(loid)s and serum heme oxygenase-1 in pregnant women: Do their distribution patterns matter?.ENVIRONMENTAL POLLUTION,286,7. |
| MLA | Li, Kexin,et al."Associations between blood heavy metal(loid)s and serum heme oxygenase-1 in pregnant women: Do their distribution patterns matter?".ENVIRONMENTAL POLLUTION 286(2021):7. |
入库方式： OAI收割
来源：地理科学与资源研究所
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