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Negative symptoms correlate with altered brain structural asymmetry in amygdala and superior temporal region in schizophrenia patients

文献类型：期刊论文

作者Huang, Zetao3; Ruan, Dun1,2; Huang, Bingjie3; Zhou, Tianhang3; Shi, Chuan3; Yu, Xin3; Chan, Raymond C. K.1,2; Wang, Yi1,2; Pu, Chengcheng3
刊名FRONTIERS IN PSYCHIATRY
出版日期2022-09-26
卷号13页码:9
ISSN号1664-0640
关键词schizophrenia predominantly negative symptoms cortical thickness asymmetry amygdala
DOI10.3389/fpsyt.2022.1000560
通讯作者Wang, Yi(pciami@163.com) ; Pu, Chengcheng(wangyi@psych.ac.cn)
英文摘要Negative symptoms play an important role in development and treatment of schizophrenia. However, brain changes relevant to negative symptoms are still unclear. This study examined brain structural abnormalities and their asymmetry in schizophrenia patients and the association with negative symptoms. Fifty-nine schizophrenia patients and 66 healthy controls undertook structural brain scans. Schizophrenia patients were further divided into predominant negative symptoms (PNS, n = 18) and non-PNS (n = 34) subgroups. Negative symptoms were assessed by the Negative Symptom Assessment (NSA). T1-weighted images were preprocessed with FreeSurfer to estimate subcortical volumes, cortical thickness and surface areas, asymmetry Index (AI) was then calculated. MANOVA was performed for group differences while partial correlations in patients were analyzed between altered brain structures and negative symptoms. Compared to healthy controls, schizophrenia patients exhibited thinner cortices in frontal and temporal regions, and decreased leftward asymmetry of superior temporal gyrus (STG) in cortical thickness. Patients with PNS exhibited increased rightward asymmetry of amygdala volumes than non-PNS subgroup. In patients, AI of cortical thickness in the STG was negatively correlated with NSA-Emotion scores (r = -0.30, p = 0.035), while AI of amygdala volume was negatively correlated with NSA-Communication (r = -0.30, p = 0.039) and NSA-Total scores (r = -0.30, p = 0.038). Our findings suggested schizophrenia patients exhibited cortical thinning and altered lateralization of brain structures. Emotion and communication dimensions of negative symptoms also correlated with the structural asymmetry of amygdala and superior temporal regions in schizophrenia patients.
收录类别SCI
WOS关键词HUMAN CEREBRAL-CORTEX ; HEMISPHERIC ASYMMETRIES ; CORTICAL THICKNESS ; SURFACE-AREA ; RECOGNITION ; EMOTION ; VOLUME ; VALIDATION ; GYRUS ; MRI
WOS研究方向Psychiatry
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:000866462700001
源URL[http://ir.psych.ac.cn/handle/311026/43519]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wang, Yi; Pu, Chengcheng
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Peking Univ, Peking Univ Hosp 6, Peking Univ Inst Mental Hlth, NHC Key Lab Mental Hlth,Natl Clic Res Ctr Mental D, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Zetao,Ruan, Dun,Huang, Bingjie,et al. Negative symptoms correlate with altered brain structural asymmetry in amygdala and superior temporal region in schizophrenia patients[J]. FRONTIERS IN PSYCHIATRY,2022,13:9.
APA Huang, Zetao.,Ruan, Dun.,Huang, Bingjie.,Zhou, Tianhang.,Shi, Chuan.,...&Pu, Chengcheng.(2022).Negative symptoms correlate with altered brain structural asymmetry in amygdala and superior temporal region in schizophrenia patients.FRONTIERS IN PSYCHIATRY,13,9.
MLA Huang, Zetao,et al."Negative symptoms correlate with altered brain structural asymmetry in amygdala and superior temporal region in schizophrenia patients".FRONTIERS IN PSYCHIATRY 13(2022):9.

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来源：心理研究所

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