Association of reduced cortical thickness and psychopathological symptoms in patients with first-episode drug-naive schizophrenia
文献类型：期刊论文
| 作者 | Zhou, Huixia3,4 ; Wang, Dongmei3,4; Cao, Bo1,2; Zhang, Xiangyang3,4
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| 刊名 | INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
 |
| 出版日期 | 2022-10-03 |
| 页码 | 9 |
| 关键词 | Cortical thickness first-episode drug-naive schizophrenia positive and negative syndrome scale psychopathological symptoms |
| ISSN号 | 1365-1501 |
| DOI | 10.1080/13651501.2022.2129067 |
| 通讯作者 | Zhang, Xiangyang(zhangxy@psych.ac.cn) |
| 英文摘要 | Objective There is growing evidence that reduced cortical thickness has been considered to be a central abnormality in schizophrenia. Brain imaging studies have demonstrated that the cerebral cortex becomes thinner in patients with first-episode schizophrenia. This study aimed to examine whether cortical thickness is altered in drug-naive schizophrenia in a Chinese Han population and the relationship between cortical thickness and clinical symptoms. Methods We compared cortical thickness in 41 schizophrenia patients and 30 healthy controls. Psychopathology of patients with schizophrenia was assessed using the Positive and Negative Syndrome Scale (PANSS). Results The cortical thickness of left banks of superior temporal sulcus, left lateral occipital gyrus, left rostral middle frontal gyrus, right inferior parietal lobule and right lateral occipital gyrus in schizophrenia patients was generally thinner compared with healthy controls. Correlation analysis revealed a negative correlation between cortical thickness of the left banks of superior temporal sulcus and general psychopathology of PANSS. Conclusions Our results suggest that cortical thickness abnormalities are already present early in the onset of schizophrenia and are associated with psychopathological symptoms, suggesting that it plays an important role in the pathogenesis and symptomatology of schizophrenia. |
| 收录类别 | SCI |
| WOS关键词 | 1ST EPISODE PSYCHOSIS ; HUMAN CEREBRAL-CORTEX ; SOCIAL COGNITION ; ANTIPSYCHOTIC-NAIVE ; NEGATIVE SYMPTOMS ; HUMAN BRAIN ; ABNORMALITIES ; DISORDER ; SEGMENTATION ; REDUCTIONS |
| 资助项目 | CAS International Cooperation Research Program[153111KYSB20190004] ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000863871100001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 资助机构 | CAS International Cooperation Research Program ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health |
| 源URL | [http://ir.psych.ac.cn/handle/311026/43537]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Xiangyang |
| 作者单位 | 1.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, McGovern Med Sch, Houston, TX 77030 USA 2.Univ Alberta, Fac Med & Dent, Dept Psychiat, Edmonton, AB, Canada 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Huixia,Wang, Dongmei,Cao, Bo,et al. Association of reduced cortical thickness and psychopathological symptoms in patients with first-episode drug-naive schizophrenia[J]. INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE,2022:9. |
| APA | Zhou, Huixia,Wang, Dongmei,Cao, Bo,&Zhang, Xiangyang.(2022).Association of reduced cortical thickness and psychopathological symptoms in patients with first-episode drug-naive schizophrenia.INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE,9. |
| MLA | Zhou, Huixia,et al."Association of reduced cortical thickness and psychopathological symptoms in patients with first-episode drug-naive schizophrenia".INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE (2022):9. |
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来源：心理研究所
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