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Regulatory Role of PFC Corticotropin-Releasing Factor System in Stress-Associated Depression Disorders: A Systematic Review

文献类型：期刊论文

作者Alizamini, Mirmohammadali Mirramezani3,4; Fattahi, Mojdeh2; Sayehmiri, Fatemeh2; Haghparast, Abbas1; Liang, Jing3,4
刊名CELLULAR AND MOLECULAR NEUROBIOLOGY
出版日期2022-10-13
页码13
关键词Depression Stress Corticotropin-releasing factor Prefrontal cortex Neuromodulation
ISSN号0272-4340
DOI10.1007/s10571-022-01289-2
通讯作者Haghparast, Abbas(Haghparast@yahoo.com) ; Liang, Jing(liangj@psych.ac.cn)
英文摘要Stress has a substantial role in formation of psychiatric disorders especially depression. Meanwhile, impairment of the prefrontal cortex (PFC) is connected to the executive and cognitive deficits induced by the stress. Given the involvement of the corticotropin-releasing factor (CRF) in stress-related processes and knowing the fact that PFC hosts a lot of CRF receptors and CRF neurotransmissions, it can worth to look at the CRF as a potential treatment for the regulation of depression disorders induced by stress within PFC region. Here, for the first time we aimed to systematically review the effectiveness of intra-PFC CRF system in the modulation of depression dysfunction caused by the stress in clinical and preclinical models/studies. Qualified researches were combined utilizing a comprehensive search of six databases including Scopus, Pubmed, Web of Science, Sciencedirect, APA PsycNet, and Embase in April 2021 and were evaluated through proper methodological quality assessment tools. Results indicate that PFC has a remarkable role in the modulation for stress-induced depression and intra-PFC CRF receptors agonist and antagonist are very considerable for regulating these types of impairments. Specifically, elevation of both CRF immunoreactivity and gene expression were observed in human studies. In the animal studies, mostly immunoreactivity or excitatory/inhibitory currents of CRF within the PFC regulated depression dysfunction. In conclusion, reviewed studies show a positive attitude toward the CRF system in regulation of the stress-induced depression; however, obviously further investigations are required to get closer to the best treatment.
收录类别SCI
WOS关键词MEDIAL PREFRONTAL CORTEX ; EARLY-LIFE STRESS ; MAJOR DEPRESSION ; CHILDHOOD ABUSE ; HORMONE ; RECEPTORS ; BRAIN ; IMPACT ; CRF ; DYSFUNCTION
资助项目Major Scientific and Technological Program of China[2021ZD0203802] ; National Natural Science Foundation of China[32071028] ; Natural Science Foundation of Beijing Municipality[5202023] ; CAS-VPST Silk Road Science Fund[GJHZ202129] ; Iran National Science Foundation[99007925] ; 2017 CAS-TWAS President's Fellowship ; World Academy of Sciences
WOS研究方向Cell Biology ; Neurosciences & Neurology
语种英语
WOS记录号WOS:000867549700001
出版者SPRINGER/PLENUM PUBLISHERS
资助机构Major Scientific and Technological Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality ; CAS-VPST Silk Road Science Fund ; Iran National Science Foundation ; 2017 CAS-TWAS President's Fellowship ; World Academy of Sciences
源URL[http://ir.psych.ac.cn/handle/311026/43543]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Haghparast, Abbas; Liang, Jing
作者单位1.Shahid Beheshti Univ Med Sci, Neurosci Res Ctr, Sch Med, POB 19615-1178, Tehran, Iran
2.Shahid Beheshti Univ Med Sci, Neurosci Res Ctr, Sch Med, Student Res Comm, Tehran, Iran
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Alizamini, Mirmohammadali Mirramezani,Fattahi, Mojdeh,Sayehmiri, Fatemeh,et al. Regulatory Role of PFC Corticotropin-Releasing Factor System in Stress-Associated Depression Disorders: A Systematic Review[J]. CELLULAR AND MOLECULAR NEUROBIOLOGY,2022:13.
APA Alizamini, Mirmohammadali Mirramezani,Fattahi, Mojdeh,Sayehmiri, Fatemeh,Haghparast, Abbas,&Liang, Jing.(2022).Regulatory Role of PFC Corticotropin-Releasing Factor System in Stress-Associated Depression Disorders: A Systematic Review.CELLULAR AND MOLECULAR NEUROBIOLOGY,13.
MLA Alizamini, Mirmohammadali Mirramezani,et al."Regulatory Role of PFC Corticotropin-Releasing Factor System in Stress-Associated Depression Disorders: A Systematic Review".CELLULAR AND MOLECULAR NEUROBIOLOGY (2022):13.

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来源：心理研究所

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