Delayed improvements in visual memory task performance among chronic schizophrenia patients after high-frequency repetitive transcranial magnetic stimulation
文献类型：期刊论文
| 作者 | Du, Xiang-Dong6; Li, Zhe6; Yuan, Nian6; Yin, Ming6; Zhao, Xue-Li6; Lv, Xiao-Li6; Zou, Si-Yun6; Zhang, Jun6; Zhang, Guang-Ya6; Li, Chuan-Wei6 |
| 刊名 | WORLD JOURNAL OF PSYCHIATRY
 |
| 出版日期 | 2022-09-19 |
| 卷号 | 12期号:9页码:1169-1182 |
| 关键词 | Cognition High-frequency repetitive transcranial magnetic stimulation Non-invasive brain stimulation Randomized controlled study Schizophrenia Visual memory deficits |
| ISSN号 | 2220-3206 |
| DOI | 10.5498/wjp.v12.i9.1169 |
| 通讯作者 | Zhang, Xiang-Yang(zhangxy@psych.ac.cn) |
| 英文摘要 | BACKGROUNDCognitive impairments are core characteristics of schizophrenia, but are largely resistant to current treatments. Several recent studies have shown that high-frequency repetitive transcranial magnetic stimulation (rTMS) of the left dor-solateral prefrontal cortex (DLPFC) can reduce negative symptoms and improve certain cognitive deficits in schizophrenia patients. However, results are inconsistent across studies.AIMTo examine if high-frequency rTMS of the DLPFC can improve visual memory deficits in patients with schizophrenia.METHODSForty-seven chronic schizophrenia patients with severe negative symptoms on stable treatment regimens were randomly assigned to receive active rTMS to the DLPFC (n = 25) or sham stimulation (n = 22) on weekdays for four consecutive weeks. Patients performed the pattern recognition memory (PRM) task from the Cambridge Neuropsychological Test Automated Battery at baseline, at the end of rTMS treatment (week 4), and 4 wk after rTMS treatment (week 8). Clinical symptoms were also measured at these same time points using the Scale for the Assessment of Negative Symptoms (SANS) and the Positive and Negative Syndrome Scale (PANSS).RESULTSThere were no significant differences in PRM performance metrics, SANS total score, SANS subscores, PANSS total score, and PANSS subscores between active and sham rTMS groups at the end of the 4-wk treatment period, but PRM performance metrics (percent correct and number correct) and changes in these metrics from baseline were significantly greater in the active rTMS group at week 8 compared to the sham group (all P < 0.05). Active rTMS treatment also significantly reduced SANS score at week 8 compared to sham treatment. Moreover, the improvement in visual memory was correlated with the reduction in negative symptoms at week 8. In contrast, there were no between-group differences in PANSS total score and subscale scores at either week 4 or week 8 (all P > 0.05).CONCLUSIONHigh-frequency transcranial magnetic stimulation improves visual memory and reduces negative symptoms in schizophrenia, but these effects are delayed, potentially due to the requirement for extensive neuroplastic changes within DLPFC networks. |
| 收录类别 | SCI |
| WOS关键词 | NONINVASIVE BRAIN-STIMULATION ; PREDOMINANT NEGATIVE SYMPTOMS ; MAJOR DEPRESSION ; WORKING-MEMORY ; RTMS ; EFFICACY ; COGNITION ; METAANALYSIS ; DIMENSIONS ; TMS |
| 资助项目 | Key Diagnosis and Treatment Program of Suzhou[LCZX201919] ; Key Diagnosis and Treatment Program of Suzhou[LCZX202016] ; Scientific and Technological Program of Suzhou[SS201752] ; Scientific and Technological Program of Suzhou[SS202069] ; Introduction Project of Suzhou Clinical Expert Team[SZYJTD201715] |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000862730500005 |
| 出版者 | BAISHIDENG PUBLISHING GROUP INC |
| 资助机构 | Key Diagnosis and Treatment Program of Suzhou ; Scientific and Technological Program of Suzhou ; Introduction Project of Suzhou Clinical Expert Team |
| 源URL | [http://ir.psych.ac.cn/handle/311026/43589]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Xiang-Yang |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Soochow Univ, Dept Psychiat, Med Coll, Suzhou 215000, Med Coll, Peoples R China 4.North China Univ Sci & Technol, Sch Psychol & Mental Hlth, Langfang 065201, Hebei Province, Peoples R China 5.Third Peoples Hosp Changshu, Dept Psychiat, Changshu 215501, Jiangsu Provinc, Peoples R China 6.Soochow Univ, Suzhou Guangji Hosp, Affiliated Guangji Hosp, Suzhou 215008, Jiangsu Provinc, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Xiang-Dong,Li, Zhe,Yuan, Nian,et al. Delayed improvements in visual memory task performance among chronic schizophrenia patients after high-frequency repetitive transcranial magnetic stimulation[J]. WORLD JOURNAL OF PSYCHIATRY,2022,12(9):1169-1182. |
| APA | Du, Xiang-Dong.,Li, Zhe.,Yuan, Nian.,Yin, Ming.,Zhao, Xue-Li.,...&Zhang, Xiang-Yang.(2022).Delayed improvements in visual memory task performance among chronic schizophrenia patients after high-frequency repetitive transcranial magnetic stimulation.WORLD JOURNAL OF PSYCHIATRY,12(9),1169-1182. |
| MLA | Du, Xiang-Dong,et al."Delayed improvements in visual memory task performance among chronic schizophrenia patients after high-frequency repetitive transcranial magnetic stimulation".WORLD JOURNAL OF PSYCHIATRY 12.9(2022):1169-1182. |
入库方式： OAI收割
来源：心理研究所
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