Clinical efficacy of idebenone in stroke patients with mild cognitive impairment, and its effect on regional homogeneity of resting-state functional magnetic resonance imaging of the brain
文献类型：期刊论文
| 作者 | Zhang, Xiaoyu1,2,3 ; Li, Juan2,3
|
| 刊名 | TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
 |
| 出版日期 | 2022-07-01 |
| 卷号 | 21期号:7页码:1557-1564 |
| 关键词 | Stroke Cognitive dysfunction Resting-state functional magnetic resonance imaging of brain Regional homogeneity Quality of life |
| ISSN号 | 1596-5996 |
| DOI | 10.4314/tjpr.v21i7.28 |
| 通讯作者 | Li, Juan(gongnliju17624@163.com) |
| 英文摘要 | Purpose: To evaluate the clinical efficacy of Idebenone in stroke patients with mild cognitive impairment, and its effect on regional homogeneity (Re Ho) of resting-state functional magnetic resonance imaging (rs-fMRI) of the brain. Methods: One hundred and twenty stroke patients with mild cognitive impairment who were admitted to the Department of Neurology of the China Rehabilitation Research Center Beijing Boai Hospital from January 2018 to January 2020 were enrolled in this study. The patients were randomly divided into control group and study group. Control group was treated with nimodipine, while the study group received a combination of nimodipine and idebenone. Results: Clinical efficacy was higher in the study group than in the control group (p < 0.05). Scores on Montreal cognitive assessment (MoCA), mini-mental state examination (MMSE), and activity of daily living scale (ADL) were significantly elevated (p < 0.05) in both groups after treatment, but scores for MoCA and ADL were significantly higher in the study group than in the control group (p < 0.05). After 6 months of treatment, there were significantly more patients with improved clinical dementia rating (CDR) in the study group than in the control group (p < 0.05). Conclusion: The use of idebenone and nimodipine for treatment of stroke patients with cognitive dysfunction leads to significant improvement in clinical outcomes, and enhancement of cognitive function and quality of life, due to improved brain function in the precuneus. However, the mechanism involved in the combination therapy-induced enhancement of cognitive function requires further investigation. |
| 收录类别 | SCI |
| WOS关键词 | INJURY |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000859868900028 |
| 出版者 | PHARMACOTHERAPY GROUP |
| 源URL | [http://ir.psych.ac.cn/handle/311026/43592]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Li, Juan |
| 作者单位 | 1.Capital Med Univ, Beijing Boai Hosp, Rehabil Sch, China Rehabil Res Ctr, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Ctr Aging Psychol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaoyu,Li, Juan. Clinical efficacy of idebenone in stroke patients with mild cognitive impairment, and its effect on regional homogeneity of resting-state functional magnetic resonance imaging of the brain[J]. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH,2022,21(7):1557-1564. |
| APA | Zhang, Xiaoyu,&Li, Juan.(2022).Clinical efficacy of idebenone in stroke patients with mild cognitive impairment, and its effect on regional homogeneity of resting-state functional magnetic resonance imaging of the brain.TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH,21(7),1557-1564. |
| MLA | Zhang, Xiaoyu,et al."Clinical efficacy of idebenone in stroke patients with mild cognitive impairment, and its effect on regional homogeneity of resting-state functional magnetic resonance imaging of the brain".TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH 21.7(2022):1557-1564. |
入库方式： OAI收割
来源：心理研究所
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