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The inconsistent mediating effect of catechol O methyl transferase Val(158)Met polymorphism on the sex difference of cognitive impairment in schizophrenia patients

文献类型：期刊论文

作者Xu, Hang4; Zhou, Yongjie3; Xiu, Meihong2; Chen, Dachun2; Wang, Weiwen1,4; Wang, Li1,4; Zhang, Xiangyang1,4
刊名FRONTIERS IN PSYCHIATRY
出版日期2022-09-20
卷号13页码:10
关键词schizophrenia catechol-O-methyl transferase (COMT) Val158Met (rs4680) sex difference cognitive function
ISSN号1664-0640
DOI10.3389/fpsyt.2022.993859
通讯作者Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要ObjectiveSchizophrenia is a multifaceted mental disorder characterized by heterogeneous positive/negative symptoms and cognitive deficits. Sex differences have been reported in various aspects of the disease. However, the underlying genetic reasons remain unelucidated. Recent studies show that the influence of COMT Val158Met (rs4680) variation is sexually dimorphic. Thus, this study aims to explore whether there is an effect of the interaction between COMT Val158Met (rs4680) polymorphism and sex on patients' clinical characteristics and cognitive function. Materials and methodsWe recruited 367 in patients with chronic schizophrenia (246 males and 121 females) and 419 healthy controls (172 males and 247 females). The cognitive performance was assessed by Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and the COMT Val158Met (rs4680) polymorphism is genotyped. The psychopathological symptoms of the patients were assessed by the Positive and Negative Syndrome Scale (PANSS). ResultsWe find that male patients had a significantly higher proportion of carrying the Val allele and Val/Val carriers exhibited more severe positive symptoms and cognitive impairment than Met carriers. COMT Val158Met (rs4680) polymorphism inconsistently mediated the relationship between sex and cognitive performance in schizophrenia patients. ConclusionThese findings suggest that COMT Val158Met (rs4680) polymorphism is associated with the risk and severity of schizophrenia in a sexually dimorphic way and contributes more to the clinical symptoms and cognitive impairment in male patients with schizophrenia.
收录类别SCI
WOS关键词COMT VAL158MET POLYMORPHISM ; METHYLTRANSFERASE GENE ; NEGATIVE SYMPTOMS ; ASSOCIATION ; GENOTYPE ; GENDER ; RISK ; POPULATION ; METABOLISM ; DOPAMINE
资助项目National Natural Science Foundation of China ; China Postdoctoral Science Foundation[81371477] ; China Postdoctoral Science Foundation[82071517] ; China Postdoctoral Science Foundation[U21A20364] ; China Postdoctoral Science Foundation[31771217] ; Special Research Assistant Program of CAS[E0BH0110] ; Chinese Academy of Sciences[E0ZZ0210] ; Key Laboratory of Mental Health, Institute of Psychology
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000863724200001
出版者FRONTIERS MEDIA SA
资助机构National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Special Research Assistant Program of CAS ; Chinese Academy of Sciences ; Key Laboratory of Mental Health, Institute of Psychology
源URL[http://ir.psych.ac.cn/handle/311026/43602]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang, Xiangyang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China
3.Shenzhen Kangning Hosp, Dept Psychiat Rehabil, Shenzhen, Guangdong, Peoples R China
4.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Hang,Zhou, Yongjie,Xiu, Meihong,et al. The inconsistent mediating effect of catechol O methyl transferase Val(158)Met polymorphism on the sex difference of cognitive impairment in schizophrenia patients[J]. FRONTIERS IN PSYCHIATRY,2022,13:10.
APA Xu, Hang.,Zhou, Yongjie.,Xiu, Meihong.,Chen, Dachun.,Wang, Weiwen.,...&Zhang, Xiangyang.(2022).The inconsistent mediating effect of catechol O methyl transferase Val(158)Met polymorphism on the sex difference of cognitive impairment in schizophrenia patients.FRONTIERS IN PSYCHIATRY,13,10.
MLA Xu, Hang,et al."The inconsistent mediating effect of catechol O methyl transferase Val(158)Met polymorphism on the sex difference of cognitive impairment in schizophrenia patients".FRONTIERS IN PSYCHIATRY 13(2022):10.

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来源：心理研究所

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