Audiovisual temporal processing in adult patients with first-episode schizophrenia and high-functioning autism
文献类型：期刊论文
| 作者 | Zhou, Han-yu5; Lai, Iris Y. S.4; Hung, Karen S. Y.4; Chan, Mandy K. M.4; Ho, Zoe T. Y.4; Lam, Jenny P. H.4; Lui, Simon S. Y.3; Chan, Raymond C. K.1,2
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| 刊名 | SCHIZOPHRENIA
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| 出版日期 | 2022-09-22 |
| 卷号 | 8期号:1页码:9 |
| DOI | 10.1038/s41537-022-00284-2 |
| 通讯作者 | Lui, Simon S. Y.(lsy570@hku.hk) ; Chan, Raymond C. K.(rckchan@psych.ac.cn) |
| 英文摘要 | Schizophrenia and autism spectrum disorder (ASD) are both neurodevelopmental disorders with altered sensory processing. Widened temporal binding window (TBW) signifies reduced sensitivity to detect stimulus asynchrony, and may be a shared feature in schizophrenia and ASD. Few studies directly compared audiovisual temporal processing ability in the two disorders. We recruited 43 adult patients with first-episode schizophrenia (FES), 35 average intelligent and verbally-fluent adult patients with high-functioning ASD and 48 controls. We employed two unisensory Temporal Order Judgement (TOJ) tasks within visual or auditory modalities, and two audiovisual Simultaneity Judgement (SJ) tasks with flash-beeps and videos of syllable utterance as stimuli. Participants with FES exhibited widened TBW affecting both speech and non-speech processing, which were not attributable to altered unisensory sensory acuity because they had normal visual and auditory TOJ thresholds. However, adults with ASD exhibited intact unisensory and audiovisual temporal processing. Lower non-verbal IQ was correlated with larger TBW width across the three groups. Taking our findings with earlier evidence in chronic samples, widened TBW is associated with schizophrenia regardless illness stage. The altered audiovisual temporal processing in ASD may ameliorate after reaching adulthood. |
| 收录类别 | SCI |
| WOS关键词 | BINDING WINDOW ; MULTISENSORY INTEGRATION ; TIME PERCEPTION ; CHILDREN ; SYNCHRONY ; PRECISION ; DISORDER ; ORDER |
| 资助项目 | National Natural Science Foundation China[31970997] ; Philip K. H. Wong Foundation ; HKU Seed Fund for Basic Research for New Staff[202009185071] |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| 出版者 | NATURE PORTFOLIO |
| WOS记录号 | WOS:000860513000001 |
| 资助机构 | National Natural Science Foundation China ; Philip K. H. Wong Foundation ; HKU Seed Fund for Basic Research for New Staff |
| 源URL | [http://ir.psych.ac.cn/handle/311026/43608]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Lui, Simon S. Y.; Chan, Raymond C. K. |
| 作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Hong Kong, Sch Clin Med, Dept Psychiat, Hong Kong, Peoples R China 4.Castle Peak Hosp, Hong Kong, Peoples R China 5.East China Normal Univ, Sch Psychol & Cognit Sci, Shanghai Key Lab Mental Hlth & Psychol Crisis Int, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Han-yu,Lai, Iris Y. S.,Hung, Karen S. Y.,et al. Audiovisual temporal processing in adult patients with first-episode schizophrenia and high-functioning autism[J]. SCHIZOPHRENIA,2022,8(1):9. |
| APA | Zhou, Han-yu.,Lai, Iris Y. S..,Hung, Karen S. Y..,Chan, Mandy K. M..,Ho, Zoe T. Y..,...&Chan, Raymond C. K..(2022).Audiovisual temporal processing in adult patients with first-episode schizophrenia and high-functioning autism.SCHIZOPHRENIA,8(1),9. |
| MLA | Zhou, Han-yu,et al."Audiovisual temporal processing in adult patients with first-episode schizophrenia and high-functioning autism".SCHIZOPHRENIA 8.1(2022):9. |
入库方式： OAI收割
来源：心理研究所
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