Neuroprotective Effects of Poria cocos (Agaricomycetes) Essential Oil on A beta 1-40 Induced Learning and Memory Deficit in Rats
文献类型：期刊论文
| 作者 | Lv, Qin6; Di, Xiaoyan5; Bian, Bo4; Li, Kai3; Guo, Jianyou1,2
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| 刊名 | INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
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| 出版日期 | 2022 |
| 卷号 | 24期号:10页码:73-82 |
| 关键词 | Alzheimer's disease Poria cocos seed oil novel object recognition Morris water maze passive avoidance memory retention medicinal mushrooms |
| ISSN号 | 1521-9437 |
| 通讯作者 | Guo, Jianyou(guojianyou@126.com) |
| 英文摘要 | Alzheimer's disease (AD) is a neurodegenerative disease that has become a leading cause of death in recent years. The present study aimed to explore the possible prophylactic effects of Poria cocos essential oil (PCEO) against memory deficits in A beta rats. Adult male Wistar rats were given A beta 1-42 via ICV injection. The effect of 30 d administration of PCEO by oral gavage was investigated. Novel object recognition (NOR) test, Morris water maze (MWM) test, and passive avoidance memory retention (PAM) task were performed. AP decreased the cognitive memory in NOR, spatial memory in MWM, and passive avoidance memory in PAM tests. In contrast, PCEO improved learning and memory in the treated group. The PCEO treatment halts the activity of AChE in the hippocampus and cortex of the AD rats. The central neuronal degeneration in A beta-injected rats was not only ascertained by the histopathological changes but also confirmed indirectly by the concomitant increase in GFAP immunostaining. The beneficial effects in AD of increasing cellular GPx, GR, CAT, Na+ K+ ATPase and GST through the administration of PCEO may not only result in protection against neurodegeneration but also result in improvement in cognitive function. PCEO may be recommended as a prophylactic and/or adjunct medication for neurodegenerative diseases. |
| 收录类别 | SCI |
| WOS关键词 | MEDICINAL MUSHROOM ; METHYL JASMONATE ; CLONING ; STRESS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences ; Mycology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000860556500001 |
| 出版者 | BEGELL HOUSE INC |
| 源URL | [http://ir.psych.ac.cn/handle/311026/43628]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Guo, Jianyou |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Nanyang Inst Technol, Henan Key Lab Zhang Zhongjing Formulae & Herbs Imm, Nanyang 473004, Peoples R China 4.Nanyang Inst Technol, Zhang Zhongjing Coll Chinese Med, Nanyang 473004, Peoples R China 5.Beijing Univ Chem Technol, Beijing 100029, Peoples R China 6.NanYang Med Coll, Dept Chinese Med, Nanyang 473061, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Qin,Di, Xiaoyan,Bian, Bo,et al. Neuroprotective Effects of Poria cocos (Agaricomycetes) Essential Oil on A beta 1-40 Induced Learning and Memory Deficit in Rats[J]. INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,2022,24(10):73-82. |
| APA | Lv, Qin,Di, Xiaoyan,Bian, Bo,Li, Kai,&Guo, Jianyou.(2022).Neuroprotective Effects of Poria cocos (Agaricomycetes) Essential Oil on A beta 1-40 Induced Learning and Memory Deficit in Rats.INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,24(10),73-82. |
| MLA | Lv, Qin,et al."Neuroprotective Effects of Poria cocos (Agaricomycetes) Essential Oil on A beta 1-40 Induced Learning and Memory Deficit in Rats".INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS 24.10(2022):73-82. |
入库方式： OAI收割
来源：心理研究所
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