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Altered BDNF levels are associated with cognitive impairment in Parkinson?s disease patients with depression

文献类型：期刊论文

作者Wang, Yu4; Bai, Li -Peng4; Liu, Wei4; Zhu, Xiao-Dong4; Zhang, Xiang -Yang1,2,3
刊名PARKINSONISM & RELATED DISORDERS
出版日期2022-10-01
卷号103页码:122-128
关键词Parkinson?s disease Depression BDNF Cognition
ISSN号1353-8020
DOI10.1016/j.parkreldis.2022.08.020
通讯作者Zhang, Xiang -Yang(zhangxy@psych.ac.cn)
英文摘要Objective: Depression and cognitive impairment are both common non-motor symptoms of Parkinson's disease (PD). Brain-derived neurotrophic factor (BDNF) may play an important role in both cognitive function and depression. In this study, we examined BDNF levels, cognitive function, and the relationship between BDNF and cognitive function in PD patients with and without depressive symptoms, which has not been reported yet.Methods: We recruited 96 PD patients with (n = 46) and without depression (n = 50) and 102 controls and examined the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and BDNF levels in all groups. The Zung Self-Rating Depression Scale (SDS) was used to assess the severity of depression and the Hoehn-Yahr staging test was used to assess motor abilities in PD patients.Results: BDNF levels were lower in patients with depressive symptoms than in patients without depressive symptoms (p < 0.01). The RBANS total score and the immediate memory, language and attention scores were lower in patients with depressive than in patients without depressive (all p < 0.05). Multiple regression analysis showed that BDNF was independent contributor to immediate memory, language and RBANS total score in the patients with depressive symptoms. BDNF and SDS were independent contributors to attention, and SDS was an independent contributor to delay memory (all p < 0.001).Conclusions: BDNF may be involved in the pathophysiology of PD patients with depressive symptoms. Moreover, the association between BDNF and cognitive performance only in patients with depressive symptoms suggest a close relationship in BDNF, cognition and depressive symptoms in PD patients.
收录类别SCI
WOS关键词VAL66MET POLYMORPHISM ; CSF ; PLASTICITY
资助项目National Science Foundation of Tianjin[17JCYBJC28100] ; National Science Foundation of Tianjin[19JCYBJC26100]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000860362600002
出版者ELSEVIER SCI LTD
资助机构National Science Foundation of Tianjin
源URL[http://ir.psych.ac.cn/handle/311026/43637]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang, Xiang -Yang
作者单位1.16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Tianjin Med Univ, Dept Neurol, Gen Hosp, Tianjin, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yu,Bai, Li -Peng,Liu, Wei,et al. Altered BDNF levels are associated with cognitive impairment in Parkinson?s disease patients with depression[J]. PARKINSONISM & RELATED DISORDERS,2022,103:122-128.
APA Wang, Yu,Bai, Li -Peng,Liu, Wei,Zhu, Xiao-Dong,&Zhang, Xiang -Yang.(2022).Altered BDNF levels are associated with cognitive impairment in Parkinson?s disease patients with depression.PARKINSONISM & RELATED DISORDERS,103,122-128.
MLA Wang, Yu,et al."Altered BDNF levels are associated with cognitive impairment in Parkinson?s disease patients with depression".PARKINSONISM & RELATED DISORDERS 103(2022):122-128.

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来源：心理研究所

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