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Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells

文献类型：期刊论文

作者Jia, Xiaohua9,10; Shen, Guodong7,8; Jia, Jia6; Zhang, Yan9; Zhang, Dan5; Li, Wanjun4; Zhang, Jianjun3; Huang, Xinglu2; Tian, Jie1,10
刊名BIOSENSORS-BASEL
出版日期2022-09-01
卷号12期号:9页码:13
关键词lineage tracing molecular imaging cancer stem cells
DOI10.3390/bios12090703
通讯作者Huang, Xinglu(huangxinglu@nankai.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要The cancer stem cells (CSC) are the roots of cancer. The CSC hypothesis may provide a model to explain the tumor cell heterogeneity. Understand the biological mechanism of CSC will help the early detection and cure of cancer. The discovery of the dynamic changes in CSC will be possible by the using of bio-engineering techniques-lineage tracing. However, it is difficult to obtain real-time, continuous, and dynamic live-imaging information using the traditional approaches that take snapshots of time points from different animals. The goal of molecular imaging is to monitor the in situ, continuous molecular changes of cells in vivo. Therefore, the most advanced bioengineering lineage tracing approach, while using a variety of molecular detection methods, will maximize the presentation of CSC. In this review, we first introduce the method of lineage tracing, and then introduce the various components of molecular images to dynamic detect the CSC. Finally, we analyze the current situation and look forward the future of CSC detection.
收录类别SCI
WOS关键词DOUBLE REPORTER ; GASTRIC-CANCER ; TUMOR ; IDENTIFICATION ; NANOPARTICLES ; EXPRESSION ; METASTASES ; COLON ; REGENERATION ; PROGENITOR
资助项目National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2017YFA0700401] ; National Natural Science Foundation of China[U21A20386] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[31871111] ; National Natural Science Foundation of China[8190070112] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; Key Research Program of Frontier Sciences[QYZDY-SSW-SMC013] ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program[19JCZDJC65300] ; CAS Key Laboratory of Mental Health[KLMH2020K02] ; Laboratory Innovation Fund of Tsinghua University[531001019] ; Laboratory Innovation Fund of Tsinghua University[100006029] ; Project of High-Level Talents Team Introduction in Zhuhai City, Zhuhai[HLHPTP20170]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation
语种英语
WOS记录号WOS:000856314800001
出版者MDPI
资助机构National Key Research and Development Program of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Key Research Program of Frontier Sciences ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program ; CAS Key Laboratory of Mental Health ; Laboratory Innovation Fund of Tsinghua University ; Project of High-Level Talents Team Introduction in Zhuhai City, Zhuhai
源URL[http://ir.psych.ac.cn/handle/311026/43658]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Huang, Xinglu; Tian, Jie
作者单位1.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med & Engn, Beijing 100191, Peoples R China
2.Nankai Univ, Coll Life Sci, Key Lab Bioact Mat Minist Educ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Xi An Jiao Tong Univ, Dept Pathol, Affiliated Hosp 3201, Hanzhong 723000, Peoples R China
5.Tsinghua Univ, Ctr Biomed Anal, Beijing 100084, Peoples R China
6.Shanxi Med Univ, Fenyang Coll, Fenyang 032200, Peoples R China
7.Southern Med Univ, Nanfang Hosp, Guangdong Prov Key Lab Precis Med Gastrointestina, Guangzhou 510515, Peoples R China
8.Southern Med Univ, Nanfang Hosp, Dept Gen Surg, Guangzhou 510515, Peoples R China
9.Gen Hosp Peoples Liberat Army, Dept Ultrasound, Beijing 100853, Peoples R China
10.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Jia, Xiaohua,Shen, Guodong,Jia, Jia,et al. Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells[J]. BIOSENSORS-BASEL,2022,12(9):13.
APA Jia, Xiaohua.,Shen, Guodong.,Jia, Jia.,Zhang, Yan.,Zhang, Dan.,...&Tian, Jie.(2022).Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells.BIOSENSORS-BASEL,12(9),13.
MLA Jia, Xiaohua,et al."Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells".BIOSENSORS-BASEL 12.9(2022):13.

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来源：心理研究所

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