Nicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation
文献类型：期刊论文
| 作者 | Hao, Keke7; Wang, Huiling4,5,7; Zhang, Yuejin3; Xie, Xinhui7; Huang, Huan7; Chen, Cheng7; Xu, Shilin7; Xu, Rui7; Shu, Chang7; Liu, Zhongchun7 |
| 刊名 | JOURNAL OF NEUROINFLAMMATION
 |
| 出版日期 | 2022-09-21 |
| 卷号 | 19期号:1页码:15 |
| 关键词 | Schizophrenia Early life stress Maternal separation Cognitive impairment Neuroinflammation Neuronal loss Nicotinamide Sirt3 |
| DOI | 10.1186/s12974-022-02591-y |
| 通讯作者 | Wang, Huiling(hlwang@whu.edu.cn) ; Wang, Gaohua(wgh6402@163.com) |
| 英文摘要 | Background Early life stress (ELS) is associated with the development of schizophrenia later in life. The hippocampus develops significantly during childhood and is extremely reactive to stress. In rodent models, ELS can induce neuroinflammation, hippocampal neuronal loss, and schizophrenia-like behavior. While nicotinamide (NAM) can inhibit microglial inflammation, it is unknown whether NAM treatment during adolescence reduces hippocampal neuronal loss and abnormal behaviors induced by ELS. Methods Twenty-four hours of maternal separation (MS) of Wistar rat pups on post-natal day (PND)9 was used as an ELS. On PND35, animals received a single intraperitoneal injection of BrdU to label dividing neurons and were given NAM from PND35 to PND65. Behavioral testing was performed. Western blotting and immunofluorescence staining were used to detect nicotinamide adenine dinucleotide (NAD(+))/Sirtuin3 (Sirt3)/superoxide dismutase 2 (SOD2) pathway-related proteins. Results Compared with controls, only MS animals in the adult stage (PND56-65) but not the adolescent stage (PND31-40) exhibited pre-pulse inhibition deficits and cognitive impairments mimicking schizophrenia symptoms. MS decreased the survival and activity of puberty-born neurons and hippocampal NAD(+) and Sirt3 expression in adulthood. These observations were related to an increase in acetylated SOD2, microglial activation, and significant increases in pro-inflammatory IL-1 beta, TNF-alpha, and IL-6 expression. All the effects of MS at PND9 were reversed by administering NAM in adolescence (PND35-65). Conclusions MS may lead to schizophrenia-like phenotypes and persistent hippocampal abnormalities. NAM may be a safe and effective treatment in adolescence to restore normal hippocampal function and prevent or ameliorate schizophrenia-like behavior. |
| 收录类别 | SCI |
| WOS关键词 | OXIDATIVE STRESS ; INFLAMMATORY RESPONSE ; LIFE-SPAN ; BRAIN ; SCHIZOPHRENIA ; CELLS ; INHIBITION ; EXPRESSION ; NEUROGENESIS ; HIPPOCAMPUS |
| 资助项目 | National Natural Science Foundation of China[91132301] ; Natural Science Foundation of Hubei Province[2014CFB732] |
| WOS研究方向 | Immunology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000857577600001 |
| 出版者 | BMC |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Hubei Province |
| 源URL | [http://ir.psych.ac.cn/handle/311026/43667]  |
| 专题 | 心理研究所_社会与工程心理学研究室 |
| 通讯作者 | Wang, Huiling; Wang, Gaohua |
| 作者单位 | 1.Sheffield Hallam Univ, Biomol Sci Res Ctr, Sheffield, S Yorkshire, England 2.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 3.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Physiol, Wuhan 430060, Peoples R China 4.Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R China 5.Wuhan Univ, Dept Psychiat, Zhongxiang Hosp, Renmin Hosp, Zhongxiang 431900, Peoples R China 6.Hubei Inst Neurol & Psychiat Res, Wuhan 430060, Peoples R China 7.Wuhan Univ, Dept Psychiat, Renmin Hosp, 238 Jiefang Rd, Wuhan 430060, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hao, Keke,Wang, Huiling,Zhang, Yuejin,et al. Nicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation[J]. JOURNAL OF NEUROINFLAMMATION,2022,19(1):15. |
| APA | Hao, Keke.,Wang, Huiling.,Zhang, Yuejin.,Xie, Xinhui.,Huang, Huan.,...&Wang, Gaohua.(2022).Nicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation.JOURNAL OF NEUROINFLAMMATION,19(1),15. |
| MLA | Hao, Keke,et al."Nicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation".JOURNAL OF NEUROINFLAMMATION 19.1(2022):15. |
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来源：心理研究所
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